ID   CHO-K1 Ed-A1
AC   CVCL_YD18
SY   Ed-A1
DR   Wikidata; Q93451727
RX   PubMed=8101392;
RX   PubMed=8782489;
RX   PubMed=9075644;
CC   Characteristics: Has reduced Na+-dependent glutamate transport activity. Have an increased permeability to small neutral molecules.
CC   Characteristics: Selection is effected by tritium suicide selection. Mutagenized cells are bathed in tritiated D-aspartate and stored so as to allow time for cells that had taken up the D-aspartate to be killed by radiation damage.
CC   Selected for resistance to: NCIt; C165595; Tritium beta radiation.
CC   Transformant: ChEBI; CHEBI:23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_0214 ! CHO-K1
SX   Female
AG   Adult
CA   Transformed cell line
DT   Created: 19-12-19; Last updated: 30-01-24; Version: 6
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RX   PubMed=8101392; DOI=10.1007/BF01233071;
RA   Ash J.F., Igo R.P. Jr., Morgan M., Grey A.;
RT   "Selection of Chinese hamster ovary cells (CHO-K1) with reduced
RT   glutamate and aspartate uptake.";
RL   Somat. Cell Mol. Genet. 19:231-243(1993).
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RX   PubMed=8782489; DOI=10.1007/BF02369900;
RA   Igo R.P. Jr., Ash J.F.;
RT   "New mutations and phenotypes associated with glutamate and aspartate
RT   transport in Chinese hamster ovary (CHO-K1) cells.";
RL   Somat. Cell Mol. Genet. 22:87-103(1996).
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RX   PubMed=9075644; DOI=10.1007/s002329900195;
RA   Tong X., Ash J.F., Caldwell K.D.;
RT   "Rapid swelling of a CHO-K1 aspartate/glutamate transport mutant in
RT   hypo-osmotic medium.";
RL   J. Membr. Biol. 156:131-139(1997).
//