ID   A375S1
AC   CVCL_Y439
DR   cancercelllines; CVCL_Y439
DR   Wikidata; Q54606878
RX   PubMed=3261584;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu61Ter (c.181G>T) (p.Gly75Val, c.224G>T); ClinVar=VCV000376309; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11730; TERT; Simple; c.1-146C>T (c.250C>T) (C250T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Miscellaneous: Not sure what is the relationship between A375.S2 and A375S1.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
DI   NCIt; C3802; Amelanotic melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0132 ! A-375
SX   Female
AG   54Y
CA   Cancer cell line
DT   Created: 07-11-14; Last updated: 05-10-23; Version: 15
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RX   PubMed=3261584; DOI=10.1016/0006-291X(88)90266-5;
RA   Nakai S., Mizuno K., Kaneta M., Hirai Y.;
RT   "A simple, sensitive bioassay for the detection of interleukin-1 using
RT   human melanoma A375 cell line.";
RL   Biochem. Biophys. Res. Commun. 154:1189-1196(1988).
//