ID   U937/UK110
AC   CVCL_Y174
SY   UK110
DR   cancercelllines; CVCL_Y174
DR   Wikidata; Q54973785
RX   PubMed=8845304;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 07-11-14; Last updated: 19-12-24; Version: 14
//
RX   PubMed=8845304;
RA   Noguchi, Kohji
RA   Naito, Mikihiko
RA   Kataoka, Shiro
RA   Yonehara, Shin
RA   Tsuruo, Takashi
RT   "A recessive mutant of the U937 cell line acquired resistance to
RT   anti-Fas and anti-p55 tumor necrosis factor receptor antibody-induced
RT   apoptosis.";
RL   Cell Growth Differ. 6:1271-1277(1995).
//