ID   CC-M3
AC   CVCL_Y099
DR   BCRC; 60450
DR   cancercelllines; CVCL_Y099
DR   Wikidata; Q54808714
RX   PubMed=1696674;
WW   Info; BCRC; -; https://www.bcrc.firdi.org.tw/attach/2019-05-28/a.pdf
CC   Problematic cell line: Contaminated. Shown to be a SW480 (or SW620) derivative (BCRC=60450). Originally thought to originate from a 80 year old female patient with a transverse colorectal carcinoma.
CC   Population: Caucasian.
CC   Doubling time: 16.6 hours (Note=At 25th passage), 16.1 hours (Note=At 50th passage) (PubMed=1696674).
CC   Sequence variation: Mutation; HGNC; HGNC:583; APC; Simple; p.Gln1338Ter (c.4012C>T); ClinVar=VCV000000801; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Val (c.35G>T); ClinVar=VCV000012583; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg273His (c.818G>A); ClinVar=VCV000012366; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro309Ser (c.925C>T); ClinVar=VCV000458575; Zygosity=Heterozygous (from parent cell line).
CC   Discontinued: BCRC; 60450; true.
CC   Derived from site: In situ; Colon; UBERON=UBERON_0001155.
DI   NCIt; C4349; Colon adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0546 ! SW480
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 07-11-14; Last updated: 10-04-25; Version: 15
//
RX   PubMed=1696674; DOI=10.1002/jso.2930440414;
RA   Cheng, Jhy-Young
RA   Meng, Ching-Liang
RA   Lin, Jih-Chang
RA   Tzeng, Ching-Cherng
RA   Chin, Li-Te
RA   Shen, Kuo-Liang
RT   "Characterization of four newly established human colorectal
RT   adenocarcinoma cell lines from Chinese patients.";
RL   J. Surg. Oncol. 44:260-267(1990).
//