ID   M397
AC   CVCL_XK00
DR   ArrayExpress; E-MTAB-5493
DR   cancercelllines; CVCL_XK00
DR   Wikidata; Q95984250
RX   PubMed=24735930;
RX   PubMed=29229836;
RX   PubMed=32393797;
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (PubMed=24735930).
CC   Omics: Metabolomics.
CC   Omics: Proteomics.
CC   Omics: Transcriptomics; RNAseq.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 19-12-19; Last updated: 10-04-25; Version: 8
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RX   PubMed=24735930; DOI=10.1186/1476-4598-13-83; PMCID=PMC4021505;
RA   Lassen A., Atefi M., Robert L., Wong D.J.L., Cerniglia M.,
RA   Comin-Anduix B., Ribas A.;
RT   "Effects of AKT inhibitor therapy in response and resistance to BRAF
RT   inhibition in melanoma.";
RL   Mol. Cancer 13:83.1-83.14(2014).
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RX   PubMed=29229836; DOI=10.1073/pnas.1712064115; PMCID=PMC5748184;
RA   Su Y.-P., Wei W., Robert L., Xue M., Tsoi J., Garcia-Diaz A.,
RA   Homet Moreno B., Kim J., Ng R.H.-Y., Lee J.W., Koya R.C.,
RA   Comin-Anduix B., Graeber T.G., Ribas A., Heath J.R.;
RT   "Single-cell analysis resolves the cell state transition and signaling
RT   dynamics associated with melanoma drug-induced resistance.";
RL   Proc. Natl. Acad. Sci. U.S.A. 114:13679-13684(2017).
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RX   PubMed=32393797; DOI=10.1038/s41467-020-15956-9; PMCID=PMC7214418;
RA   Su Y.-P., Ko M.E., Cheng H.-J., Zhu R.-H., Xue M., Wang J.K., Lee J.W.,
RA   Frankiw L., Xu A., Wong S., Robert L., Takata K., Yuan D., Lu Y.,
RA   Huang S., Ribas A., Levine R.D., Nolan G.P., Wei W., Plevritis S.K.,
RA   Li G.-D., Baltimore D., Heath J.R.;
RT   "Multi-omic single-cell snapshots reveal multiple independent
RT   trajectories to drug tolerance in a melanoma cell line.";
RL   Nat. Commun. 11:2345.1-2345.12(2020).
//