ID   THP-1 TLR9 mCherry
AC   CVCL_XI47
DR   cancercelllines; CVCL_XI47
DR   Wikidata; Q98133245
RX   CelloPub=CLPUB00539;
RX   CelloPub=CLPUB00540;
CC   Population: Japanese.
CC   Characteristics: Transfected with a Tet-on system so as to induce the expression of a TLR9-mCherry fusion protein with the addition of doxycycline to the culture medium.
CC   Sequence variation: Gene fusion; HGNC; HGNC:2457; CSNK2A1 + HGNC; HGNC:13917; DDX39B; Name(s)=CSNK2A1-DDX39B (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; HGNC:7132; KMT2A + HGNC; HGNC:7136; MLLT3; Name(s)=KMT2A-MLLT3, MLL-MLLT3, MLL-AF9 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000039648; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg174fs*3 (c.520_545del26); Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=FPbase; ZERB6; mCherry (Note=Red fluorescent protein derived from drFP583 (dsRed)).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:15633; TLR9.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P06492; Human herpesvirus 1 (HHV-1) VP16 (UL28) (Note=With p.Met1_Arg360del).
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9163; Childhood acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0006 ! THP-1
SX   Male
AG   1Y
CA   Cancer cell line
DT   Created: 19-12-19; Last updated: 14-08-25; Version: 13
//
RX   CelloPub=CLPUB00540;
RA   Wang, Caroline
RT   "Characterization of a model cell line to study Toll-like receptor 9
RT   signaling and trafficking.";
RL   Thesis MSc (2019); Norwegian University of Science and Technology; Trondheim; Norway.
//
RX   CelloPub=CLPUB00539;
RA   Cemalovic, Ena
RT   "TLR9 trafficking and signaling.";
RL   Thesis MSc (2019); Norwegian University of Science and Technology; Trondheim; Norway.
//