ID   HiB5
AC   CVCL_XF91
DR   Wikidata; Q94208147
RX   PubMed=1878969;
RX   PubMed=12112642;
RX   PubMed=22457755;
WW   Info; Thermo Fisher; -; https://www.thermofisher.com/ch/en/home/technical-resources/cell-lines/h/cell-lines-detail-61.html
CC   Characteristics: Proliferates at the permissive temperature (33 Celsius). Differentiates at the restrictive temperature (37 Celsius).
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; SV40 large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA58).
CC   Derived from site: In situ; Embryonic brain, hippocampus; UBERON=UBERON_0006238+UBERON_0002421.
CC   Breed/subspecies: Sprague Dawley; RS=RS_0000681.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Sex unspecified
AG   16FD
CA   Conditionally immortalized cell line
DT   Created: 06-09-19; Last updated: 10-04-25; Version: 11
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RX   PubMed=1878969; DOI=10.1016/0092-8674(91)90116-g;
RA   Renfranz P.J., Cunningham M.G., McKay R.D.G.;
RT   "Region-specific differentiation of the hippocampal stem cell line
RT   HiB5 upon implantation into the developing mammalian brain.";
RL   Cell 66:713-729(1991).
//
RX   PubMed=12112642; DOI=10.1002/jgm.268;
RA   Rosenqvist N., Hard af Segerstad C., Samuelsson C., Johansen J.,
RA   Lundberg C.;
RT   "Activation of silenced transgene expression in neural precursor cell
RT   lines by inhibitors of histone deacetylation.";
RL   J. Gene Med. 4:248-257(2002).
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RX   PubMed=22457755; DOI=10.1371/journal.pone.0033352; PMCID=PMC3310062;
RA   Subburaju S., Benes F.M.;
RT   "Induction of the GABA cell phenotype: an in vitro model for studying
RT   neurodevelopmental disorders.";
RL   PLoS ONE 7:e33352.1-e33352.10(2012).
//