ID   SK-HEP-1-Cas9-726
DR   cancercelllines; CVCL_XD84
DR   CCRID; 1101HUM-PUMC000726
DR   Wikidata; Q98132644
CC   Problematic cell line: Misclassified. Parent cell line (SK-HEP-1) was originally described as originating from an adenocarcinoma of liver and thus classified as hepatocellular carcinoma. Later studies show that it most probably has arisen from endothelial cells.
CC   Population: Caucasian.
CC   Characteristics: Transfected with a Cas9-Flag-Neo construct.
CC   Karyotypic information: Has lost chromosome Y (from parent cell line).
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; Q99ZW2; Streptomyces pyogenes Cas9.
CC   Transfected with: UniProtKB; P00552; Transposon Tn5 neo.
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
CC   Cell type: Endothelial cell; CL=CL_0000115.
ST   Source(s): CCRID=1101HUM-PUMC000726
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D12S391: 18
ST   D13S317: 8,12
ST   D16S539: 12
ST   D18S51: 13,15
ST   D19S433: 12,15.2
ST   D21S11: 29,31,32
ST   D2S1338: 20,23
ST   D3S1358: 16
ST   D5S818: 10,13
ST   D6S1043: 11
ST   D7S820: 8,11
ST   D8S1179: 13,14
ST   FGA: 17
ST   Penta E: 13,21
ST   TH01: 7,9
ST   TPOX: 9
ST   vWA: 14,17
DI   NCIt; C7106; Liver and intrahepatic bile duct epithelial neoplasm
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0525 ! SK-HEP-1
SX   Male
AG   52Y
CA   Cancer cell line
DT   Created: 06-09-19; Last updated: 02-05-24; Version: 12