ID   KK-1 [Human leukemia]
AC   CVCL_X908
SY   KK1
DR   cancercelllines; CVCL_X908
DR   CGH-DB; 9028-4
DR   IARC_TP53; 26998
DR   Wikidata; Q54899965
RX   CelloPub=CLPUB00592;
RX   PubMed=1861543;
RX   PubMed=9172809;
RX   PubMed=9596675;
RX   PubMed=10190897;
RX   PubMed=10570904;
RX   PubMed=15638862;
RX   PubMed=19220422;
RX   PubMed=19710698;
RX   PubMed=27193821;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Sequence variation: Mutation; HGNC; HGNC:9065; PLCG1; Simple; p.Ser345Phe (c.1034C>T); Zygosity=Heterozygous (CelloPub=CLPUB00592).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Val31Ile (c.91G>A); ClinVar=VCV000127827; Zygosity=Unspecified (PubMed=19220422; PubMed=19710698).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Pro152Arg (c.455C>G); ClinVar=VCV000824998; Zygosity=Unspecified (PubMed=19220422; PubMed=19710698).
CC   Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C3184; Adult T-cell leukemia/lymphoma
DI   ORDO; Orphanet_86875; Adult T-cell leukemia/lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_X909 ! KK-5
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 19-12-24; Version: 14
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RX   CelloPub=CLPUB00592;
RA   Patel V.M.;
RT   "Functional interrogations of phospholipase c gamma 1 (PLCG1)
RT   mutations in Sezary syndrome.";
RL   Thesis PhD (2019); King's College London; London; United Kingdom.
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RX   PubMed=1861543; DOI=10.1016/0145-2126(91)90031-N;
RA   Yamada Y., Nagata Y., Kamihira S., Tagawa M., Ichimaru M.,
RA   Tomonaga M., Shiku H.;
RT   "IL-2-dependent ATL cell lines with phenotypes differing from the
RT   original leukemia cells.";
RL   Leuk. Res. 15:619-625(1991).
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RX   PubMed=9172809; DOI=10.3109/10428199609093442;
RA   Yamada Y., Ohmoto Y., Hata T., Yamamura M., Murata K., Tsukasaki K.,
RA   Kohno T., Chen Y.-X., Kamihira S., Tomonaga M.;
RT   "Features of the cytokines secreted by adult T cell leukemia (ATL)
RT   cells.";
RL   Leuk. Lymphoma 21:443-447(1996).
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RX   PubMed=9596675; DOI=10.1182/blood.V91.11.4265;
RA   Yamada Y., Sugawara K., Hata T., Tsuruta K., Moriuchi R., Maeda T.,
RA   Atogami S., Murata K., Fujimoto K., Kohno T., Tsukasaki K.,
RA   Tomonaga M., Hirakata Y.-i., Kamihira S.;
RT   "Interleukin-15 (IL-15) can replace the IL-2 signal in IL-2-dependent
RT   adult T-cell leukemia (ATL) cell lines: expression of IL-15 receptor
RT   alpha on ATL cells.";
RL   Blood 91:4265-4272(1998).
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RX   PubMed=10190897; DOI=10.1084/jem.189.7.1063; PMCID=PMC2193006;
RA   Maeda T., Yamada Y., Moriuchi R., Sugahara K., Tsuruda K., Joh T.,
RA   Atogami S., Tsukasaki K., Tomonaga M., Kamihira S.;
RT   "Fas gene mutation in the progression of adult T cell leukemia.";
RL   J. Exp. Med. 189:1063-1071(1999).
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RX   PubMed=10570904; DOI=10.1007/s100380050178;
RA   Ariyama Y., Mori T., Shinomiya T., Sakabe T., Fukuda Y., Kanamaru A.,
RA   Yamada Y., Isobe M., Seto M., Nakamura Y., Inazawa J.;
RT   "Chromosomal imbalances in adult T-cell leukemia revealed by
RT   comparative genomic hybridization: gains at 14q32 and 2p16-22 in cell
RT   lines.";
RL   J. Hum. Genet. 44:357-363(1999).
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RX   PubMed=15638862; DOI=10.1111/j.1365-2141.2004.05289.x;
RA   Hasegawa H., Yamada Y., Harasawa H., Tsuji T., Murata K., Sugahara K.,
RA   Tsuruda K., Ikeda S., Imaizumi Y., Tomonaga M., Masuda M., Takasu N.,
RA   Kamihira S.;
RT   "Sensitivity of adult T-cell leukaemia lymphoma cells to tumour
RT   necrosis factor-related apoptosis-inducing ligand.";
RL   Br. J. Haematol. 128:253-265(2005).
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RX   PubMed=19220422; DOI=10.1111/j.1600-0609.2009.01211.x;
RA   Kamihira S., Terada C., Sasaki D., Yanagihara K., Tsukasaki K.,
RA   Hasegawa H., Yamada Y.;
RT   "Aberrant p53 protein expression and function in a panel of
RT   hematopoietic cell lines with different p53 mutations.";
RL   Eur. J. Haematol. 82:301-307(2009).
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RX   PubMed=19710698; DOI=10.1038/leu.2009.171;
RA   Hasegawa H., Yamada Y., Iha H., Tsukasaki K., Nagai K., Atogami S.,
RA   Sugahara K., Tsuruda K., Ishizaki A., Kamihira S.;
RT   "Activation of p53 by Nutlin-3a, an antagonist of MDM2, induces
RT   apoptosis and cellular senescence in adult T-cell leukemia cells.";
RL   Leukemia 23:2090-2101(2009).
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RX   PubMed=27193821; DOI=10.1111/cas.12971; PMCID=PMC4982578;
RA   Hasegawa H., Bissonnette R.P., Gillings M., Sasaki D., Taniguchi H.,
RA   Kitanosono H., Tsuruda K., Kosai K., Uno N., Morinaga Y., Imaizumi Y.,
RA   Miyazaki Y., Yanagihara K.;
RT   "Induction of apoptosis by HBI-8000 in adult T-cell leukemia/lymphoma
RT   is associated with activation of Bim and NLRP3.";
RL   Cancer Sci. 107:1124-1133(2016).
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