ID   TK-6 [Human leukemia]
AC   CVCL_X907
SY   TK6
DR   ArrayExpress; E-MTAB-7721
DR   ArrayExpress; E-MTAB-7722
DR   BioSample; SAMN03473400
DR   CGH-DB; 9213-4
DR   Cosmic; 1483366
DR   DSMZ; ACC-723
DR   DSMZCellDive; ACC-723
DR   Wikidata; Q54972529
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=7475285;
RX   PubMed=9737692;
RX   PubMed=10071072;
RX   PubMed=10576511;
RX   PubMed=31160637;
CC   Part of: LL-100 blood cancer cell line panel.
CC   Population: Japanese.
CC   Doubling time: ~60-72 hours (DSMZ=ACC-723).
CC   HLA typing: A*02:06:01,33:03:01; B*40:02:01,44:03:01; C*03:04:01;14:03 (DSMZCellDive=ACC-723).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511; PubMed=31160637).
CC   Sequence variation: Gene fusion; HGNC; HGNC:28904; AIF1L + HGNC; HGNC:6871; MAPK1; Name(s)=MAPK1-AIF1L (PubMed=31160637).
CC   Sequence variation: Mutation; HGNC; HGNC:7545; MYB; Unexplicit; Rearranged and truncated; Zygosity=Unspecified (PubMed=9737692).
CC   Omics: Genomics; Whole exome sequencing.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
ST   Source(s): DSMZ=ACC-723
ST   Amelogenin: X,Y
ST   CSF1PO: 10,11
ST   D13S317: 8,13
ST   D16S539: 9,12
ST   D18S51: 12,14
ST   D19S433: 13,14
ST   D21S11: 29,32.2
ST   D2S1338: 19,24
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 8,11
ST   D8S1179: 12,14
ST   FGA: 23,25
ST   Penta D: 11,12
ST   Penta E: 10,19
ST   TH01: 6,9
ST   TPOX: 8
ST   vWA: 15,16
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   30Y
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 10-04-25; Version: 20
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RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff, Cord C.
RA   Habig, Silke
RA   Fombonne, Severine
RA   Matsuo, Yoshinobu
RA   Drexler, Hans Gunther
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//
RX   PubMed=9737692; DOI=10.1038/sj.leu.2401113;
RA   Tomita, Akihiro
RA   Watanabe, Takashi
RA   Kosugi, Hiroshi
RA   Ohashi, Haruhiko
RA   Uchida, Toshiki
RA   Kinoshita, Tomohiro
RA   Mizutani, Shuki
RA   Hotta, Tomomitsu
RA   Murate, Takashi
RA   Seto, Masao
RA   Saito, Hiroshi
RT   "Truncated c-Myb expression in the human leukemia cell line TK-6.";
RL   Leukemia 12:1422-1429(1998).
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler, Hans Gunther
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=7475285;
RA   Watanabe, Takashi
RA   Kataoka, Takae
RA   Mizuta, Shuichi
RA   Kobayashi, Masahide
RA   Uchida, Toshiki
RA   Imai, K.
RA   Wada, Hiroyoshi
RA   Kinoshita, Tomohiro
RA   Murate, Takashi
RA   Mizutani, Shuki
RA   Saito, Hidehiko
RA   Hotta, Tomomitsu
RT   "Establishment and characterization of a novel cell line, TK-6,
RT   derived from T cell blast crisis of chronic myelogenous leukemia, with
RT   the secretion of parathyroid hormone-related protein.";
RL   Leukemia 9:1926-1934(1995).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler, Hans Gunther
RA   MacLeod, Roderick A.F.
RA   Uphoff, Cord C.
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=31160637; DOI=10.1038/s41598-019-44491-x; PMCID=PMC6547646;
RA   Quentmeier, Hilmar
RA   Pommerenke, Claudia
RA   Dirks, Wilhelm Gerhard
RA   Eberth, Sonja
RA   Koeppel, Max
RA   MacLeod, Roderick A.F.
RA   Nagel, Stefan
RA   Steube, Klaus G.
RA   Uphoff, Cord C.
RA   Drexler, Hans Gunther
RT   "The LL-100 panel: 100 cell lines for blood cancer studies.";
RL   Sci. Rep. 9:8218.1-8218.14(2019).
//