ID   U87-CD4 clone 2
AC   CVCL_X702
SY   U87MG clone 2
DR   BEI_Resources; ARP-2187
DR   cancercelllines; CVCL_X702
DR   Wikidata; Q54973747
RX   PubMed=2293663;
RX   PubMed=8095307;
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:1678; CD4.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Transposon Tn5 neo.
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 19-12-24; Version: 14
//
RX   PubMed=2293663; DOI=10.1128/JVI.64.1.215-221.1990; PMCID=PMC249089;
RA   Chesebro B.W., Buller R., Portis J.L., Wehrly K.;
RT   "Failure of human immunodeficiency virus entry and infection in
RT   CD4-positive human brain and skin cells.";
RL   J. Virol. 64:215-221(1990).
//
RX   PubMed=8095307; DOI=10.1128/JVI.67.4.2355-2359.1993; PMCID=PMC240396;
RA   Dragic T., Alizon M.;
RT   "Different requirements for membrane fusion mediated by the envelopes
RT   of human immunodeficiency virus types 1 and 2.";
RL   J. Virol. 67:2355-2359(1993).
//