ID   CEM.NKR-CCR5-Luc
AC   CVCL_X624
SY   CEM-NKR-CCR5-Luc; CEM-NKr-CCR5-Luc; CEM.NKR CCR5+Luc+; CEM-R5
DR   BEI_Resources; ARP-5198
DR   cancercelllines; CVCL_X624
DR   Wikidata; Q54809265
RX   PubMed=11162843;
CC   Population: Caucasian.
CC   Characteristics: Resistant to NK cell-mediated cell lysis (from parent cell line).
CC   Characteristics: The luciferase reporter gene is under the transcriptional control of the HIV-2 LTR.
CC   Sequence variation: Gene fusion; HGNC; HGNC:13222; BCL11B + HGNC; HGNC:2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Genetic integration: Method=Transfection/transduction; Gene=HGNC; HGNC:1606; CCR5.
CC   Genetic integration: Method=Transfection/transduction; Gene=UniProtKB; P08659; Firefly luciferase.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_X623 ! CEM.NKR-CCR5
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 19-12-24; Version: 22
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RX   PubMed=11162843; DOI=10.1006/viro.2000.0780;
RA   Spenlehauer C., Gordon C.A., Trkola A., Moore J.P.;
RT   "A luciferase-reporter gene-expressing T-cell line facilitates
RT   neutralization and drug-sensitivity assays that use either R5 or X4
RT   strains of human immunodeficiency virus type 1.";
RL   Virology 280:292-300(2001).
//