ID   CEM.NKR-CCR5
AC   CVCL_X623
SY   CEM.NKR CCR5+
DR   CLO; CLO_0037252
DR   cancercelllines; CVCL_X623
DR   HIVReagentProgram; ARP-4376
DR   Wikidata; Q54809263
RX   PubMed=10516002;
WW   https://www.quora.com/What-are-features-of-the-CEM-NKR-CCR5-cell-line
CC   Population: Caucasian.
CC   Characteristics: Resistant to NK cell-mediated cell lysis (from parent cell line).
CC   Sequence variation: Gene fusion; HGNC; 13222; BCL11B + HGNC; 2488; NKX2-5; Name(s)=NKX2.5-BCL11B (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg465Cys (c.1393C>T); ClinVar=VCV000376414; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 3765; FLT3; Simple; p.Ala627Thr (c.1879G>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Gly12Asp (c.35G>A); ClinVar=VCV000012582; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1593_Arg1594insProArgLeuProHisAsnSerSerPheHisPheLeu (c.4780_4781ins36); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Pro2412Thr (c.7234C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg175His (c.524G>A); ClinVar=VCV000012374; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: HGNC; 1606; CCR5.
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_X622 ! CEM.NKR
SX   Female
AG   3Y11M
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 05-10-23; Version: 17
//
RX   PubMed=10516002; DOI=10.1128/JVI.73.11.8966-8974.1999;
RA   Trkola A., Matthews J., Gordon C., Ketas T.J., Moore J.P.;
RT   "A cell line-based neutralization assay for primary human
RT   immunodeficiency virus type 1 isolates that use either the CCR5 or the
RT   CXCR4 coreceptor.";
RL   J. Virol. 73:8966-8974(1999).
//