ID   Ramos-Blue KD-Myd
AC   CVCL_X592
DR   Wikidata; Q54949203
WW   https://www.invivogen.com/ramos-blue-kdmyd
CC   Population: Caucasian.
CC   Characteristics: MyD88-deficient. This cell line does not respond or respond weakly to the activation of receptors which signaling is dependent on MyD88, such as TLR7 and TLR9. However, they are still responsive to TLR3 which is MyD88-independent (InvivoGen).
CC   Characteristics: SEAP (secreted ALPP) reporter cell line, in this cell line SEAP is under the control of a NF-KappaB/AP-1 promoter.
CC   Virology: EBV-negative.
CC   Knockout cell: Method=shRNA knockdown; HGNC; 7562; MYD88.
CC   Sequence variation: Gene fusion; HGNC; 5477; IGH + HGNC; 7553; MYC; Name(s)=MYC-IGH (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ile254Asp (c.760_761AT>GA); Zygosity=Homozygous (from parent cell line).
CC   Transfected with: HGNC; 439; ALPP.
CC   Transfected with: UniProtKB; P17493; Streptoalloteichus hindustanus ble (BleoR).
CC   Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Ascites; UBERON=UBERON_0007795.
CC   Cell type: B-cell; CL=CL_0000236.
DI   NCIt; C2912; Burkitt lymphoma
DI   ORDO; Orphanet_543; Burkitt lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0597 ! Ramos
SX   Male
AG   3Y
CA   Cancer cell line
DT   Created: 05-09-14; Last updated: 02-05-24; Version: 20
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