ID   Tyler2
AC   CVCL_WS65
SY   TYLER2
DR   Wikidata; Q98133704
RX   DOI=10.1158/1538-7445.AM2012-5258;
RX   PubMed=31175136;
CC   Sequence variation: Mutation; VGNC; VGNC:38093; ARID1A; Simple; p.Ala901fs (c.2700_2701insA); Zygosity=Heterozygous (PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; VGNC:38297; ATRX; Simple; p.Cys1810Ter (c.5430T>A); Zygosity=Homozygous (PubMed=31175136).
CC   Sequence variation: Mutation; VGNC; VGNC:38514; BRAF; Simple; p.Val588Glu (c.1763T>A); Zygosity=Heterozygous (PubMed=31175136).
CC   Omics: Genomics; Whole exome sequencing.
CC   Derived from site: In situ; Urinary bladder; UBERON=UBERON_0001255.
CC   Breed/subspecies: Beagle; VBO=VBO_0200131.
ST   Source(s): PubMed=31175136
ST   Dog FHC2010: 239
ST   Dog FHC2054: 151
ST   Dog FHC2079: 271,275
ST   Dog PEZ1: 119
ST   Dog PEZ3: 134
ST   Dog PEZ5: 107,111
ST   Dog PEZ6: 175,183
ST   Dog PEZ8: 227,236
ST   Dog PEZ12: 263,281
ST   Dog PEZ20: 176,180
DI   NCIt; C128126; Canine transitional cell carcinoma
OX   NCBI_TaxID=9615; ! Canis lupus familiaris (Dog)
OI   CVCL_WS64 ! Tyler1
SX   Male
AG   8Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 10-04-25; Version: 9
//
RX   DOI=10.1158/1538-7445.AM2012-5258;
RA   Sledge D.G., Kiupel M., Madrill N., McNiel E.A.;
RT   "Characterization of canine lower urinary tract carcinoma cell lines
RT   with variable DNA mismatch repair proficiency derived from a single
RT   tumor.";
RL   Cancer Res. 72 Suppl. 8:5258-5258(2012).
//
RX   PubMed=31175136; DOI=10.1158/1535-7163.MCT-18-1346; PMCID=PMC6679748;
RA   Das S., Idate R., Cronise K.E., Gustafson D.L., Duval D.L.;
RT   "Identifying candidate druggable targets in canine cancer cell lines
RT   using whole-exome sequencing.";
RL   Mol. Cancer Ther. 18:1460-1471(2019).
//