ID   LN-2540GS
AC   CVCL_WS28
DR   cancercelllines; CVCL_WS28
DR   GEO; GSM1469039
DR   GEO; GSM2794461
DR   GEO; GSM2794462
DR   GEO; GSM2794463
DR   GEO; GSM2889485
DR   Wikidata; Q95982662
RX   PubMed=21097691;
RX   PubMed=22570425;
RX   PubMed=25622821;
RX   PubMed=27717037;
CC   Characteristics: Glioma-derived sphere line. Tumorigenic in nude mice.
CC   Sequence variation: Gene deletion; HGNC; HGNC:1787; CDKN2A; Zygosity=Hemizygous (PubMed=22570425).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; c.253+5G>A; ClinVar=VCV000427618; Zygosity=Heterozygous (PubMed=22570425).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Unexplicit; Ex1-9del; Zygosity=Heterozygous (PubMed=22570425).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Trp (c.742C>T); ClinVar=VCV000012347; Zygosity=Homozygous (PubMed=22570425).
CC   Omics: Genomics; DNA methylation analysis.
CC   Omics: Transcriptomics; Microarray.
CC   Omics: Variations; Array-based CGH.
CC   Derived from site: In situ; Brain, left frontal lobe; UBERON=UBERON_0002811.
ST   Source(s): PubMed=22570425
ST   Amelogenin: X,Y
ST   CSF1PO: 11
ST   D13S317: 11,13
ST   D16S539: 11,12
ST   D18S51: 16
ST   D21S11: 29,31
ST   D3S1358: 16,18
ST   D5S818: 11
ST   D7S820: 9,10
ST   D8S1179: 12,15
ST   FGA: 23
ST   Penta D: 9,11
ST   Penta E: 11
ST   TH01: 8,10
ST   TPOX: 8
ST   vWA: 15,17
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   51Y
CA   Cancer cell line
DT   Created: 05-07-19; Last updated: 10-04-25; Version: 11
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RX   PubMed=21097691; DOI=10.1158/1078-0432.CCR-10-1931;
RA   Sciuscio D., Diserens A.-C., van Dommelen K., Martinet D., Jones G.,
RA   Janzer R.-C., Pollo C., Hamou M.-F., Kaina B., Stupp R., Levivier M.,
RA   Hegi M.E.;
RT   "Extent and patterns of MGMT promoter methylation in glioblastoma- and
RT   respective glioblastoma-derived spheres.";
RL   Clin. Cancer Res. 17:255-266(2011).
//
RX   PubMed=22570425; DOI=10.1093/neuonc/nos072; PMCID=PMC3367844;
RA   Bady P., Diserens A.-C., Castella V., Kalt S., Heinimann K.,
RA   Hamou M.-F., Delorenzi M., Hegi M.E.;
RT   "DNA fingerprinting of glioma cell lines and considerations on
RT   similarity measurements.";
RL   Neuro-oncol. 14:701-711(2012).
//
RX   PubMed=25622821; DOI=10.1186/s13059-015-0583-7; PMCID=PMC4342872;
RA   Kurscheid S., Bady P., Sciuscio D., Samarzija I., Shay T.,
RA   Vassallo I., Van Criekinge W., Daniel R.T., van den Bent M.J.,
RA   Marosi C., Weller M., Mason W.P., Domany E., Stupp R., Delorenzi M.,
RA   Hegi M.E.;
RT   "Chromosome 7 gain and DNA hypermethylation at the HOXA10 locus are
RT   associated with expression of a stem cell related HOX-signature in
RT   glioblastoma.";
RL   Genome Biol. 16:16.1-16.15(2015).
//
RX   PubMed=27717037; DOI=10.1002/nbm.3610;
RA   Porcari P., Hegi M.E., Lei H.-X., Hamou M.-F., Vassallo I., Capuani S.,
RA   Gruetter R., Mlynarik V.;
RT   "Early detection of human glioma sphere xenografts in mouse brain
RT   using diffusion MRI at 14.1 T.";
RL   NMR Biomed. 29:1577-1589(2016).
//