ID   HTC75
AC   CVCL_WM79
DR   cancercelllines; CVCL_WM79
DR   Wikidata; Q94305579
RX   PubMed=9034193;
RX   PubMed=9476899;
RX   PubMed=19864690;
CC   Population: Caucasian.
CC   Characteristics: Transfected with the tetracycline transactivator (tTA) protein, a fusion of tetR with the activation domain of HSV-1 VP16.
CC   Sequence variation: Gene deletion; HGNC; 1787; CDKN2A; Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 5382; IDH1; Simple; p.Arg132Cys (c.394C>T); ClinVar=VCV000375891; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Transfected with: UniProtKB; P04483; Escherichia coli Tn10 tetR.
CC   Transfected with: UniProtKB; P06492; Human herpesvirus 1 VP16 (UL28) (with p.Met1_Arg360del).
CC   Transfected with: UniProtKB; P00557; Escherichia coli hygromycin-B 4-O-kinase (hph) (HygR).
CC   Derived from site: In situ; Bone, pelvis, acetabulum; UBERON=UBERON_0001269.
ST   Source(s): PubMed=19864690
ST   CSF1PO: 12
ST   D13S317: 12,14
ST   D16S539: 9,12
ST   D18S51: 12,18
ST   D19S433: 13.2,15
ST   D21S11: 28,30
ST   D2S1338: 25,26
ST   D3S1358: 16
ST   D5S818: 11,13
ST   D8S1179: 13,14
ST   FGA: 22,25
ST   TH01: 6
ST   TPOX: 8
ST   vWA: 14,19
DI   NCIt; C3043; Fibrosarcoma
DI   ORDO; Orphanet_2030; Fibrosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0317 ! HT-1080
SX   Male
AG   35Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 05-10-23; Version: 11
//
RX   PubMed=9034193; DOI=10.1038/385740a0;
RA   van Steensel B., de Lange T.;
RT   "Control of telomere length by the human telomeric protein TRF1.";
RL   Nature 385:740-743(1997).
//
RX   PubMed=9476899; DOI=10.1016/S0092-8674(00)80932-0;
RA   van Steensel B., Smogorzewska A., de Lange T.;
RT   "TRF2 protects human telomeres from end-to-end fusions.";
RL   Cell 92:401-413(1998).
//
RX   PubMed=19864690; DOI=10.1074/jbc.M109.038026;
RA   Takai K.K., Hooper S., Blackwood S., Gandhi R., de Lange T.;
RT   "In vivo stoichiometry of shelterin components.";
RL   J. Biol. Chem. 285:1457-1467(2010).
//