ID   NCI-H524-A
AC   CVCL_WM69
SY   NCI-H524A
DR   cancercelllines; CVCL_WM69
DR   Wikidata; Q95993590
RX   PubMed=1845952;
RX   PubMed=2473086;
RX   PubMed=7720728;
CC   Population: Caucasian.
CC   Characteristics: Established from parent cell line by selection of the adherent cells.
CC   Sequence variation: Mutation; HGNC; 9884; RB1; Simple; p.Ser576Ter (c.1727C>G); Zygosity=Homozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Thr155Asn (c.464C>A); ClinVar=VCV000406564; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000027.
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1568 ! NCI-H524
SX   Male
AG   63Y
CA   Cancer cell line
DT   Created: 24-05-19; Last updated: 05-10-23; Version: 7
//
RX   PubMed=1845952; DOI=10.1002/1097-0142(19910201)67:3<619::AID-CNCR2820670317>3.0.CO;2-Y;
RA   Broers J.L.V., Mijnheere E.P., Rot M.K., Schaart G., Sijlmans A.,
RA   Boerman O.C., Ramaekers F.C.S.;
RT   "Novel antigens characteristic of neuroendocrine malignancies.";
RL   Cancer 67:619-633(1991).
//
RX   PubMed=2473086; DOI=10.1242/jcs.91.1.91;
RA   Broers J.L.V., Rot M.K., Oostendorp T., Bepler G., de Leij L.F.M.H.,
RA   Carney D.N., Vooijs G.P., Ramaekers F.C.S.;
RT   "Spontaneous changes in intermediate filament protein expression
RT   patterns in lung cancer cell lines.";
RL   J. Cell Sci. 91:91-108(1988).
//
RX   PubMed=7720728;
RA   Senden N.H.M., van de Velde H.J.K., Broers J.L.V., Timmer E.D.J.,
RA   Kuijpers H.J.H., Roebroek A.J.M., Van de Ven W.J.M., Ramaekers F.C.S.;
RT   "Subcellular localization and supramolecular organization of
RT   neuroendocrine-specific protein B (NSP-B) in small cell lung cancer.";
RL   Eur. J. Cell Biol. 65:341-353(1994).
//