ID   GG-CL
AC   CVCL_WK94
DR   ABM; T0596
DR   Wikidata; Q93560944
RX   PubMed=9528980;
RX   PubMed=9564855;
RX   PubMed=9675014;
CC   Characteristics: Responds to stimulation by PRL, estradiol and cAMP, making the cells a useful model for studies involving gene expression and regulation of luteal cells (ABM=T0596).
CC   Characteristics: At the permissive temperature (33 Celsius) these cells are small and compact and divide. At the non-permissive temperature (40 Celsius) the cells assume a monolayer appearance and become differentiated (PubMed=9528980).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40) (Note=tsA209).
CC   Derived from site: In situ; Ovary, corpus luteum; UBERON=UBERON_0002512.
CC   Cell type: Luteal cell; CL=CL_0000175.
CC   Breed/subspecies: Sprague Dawley; RS=RS_0000681.
OX   NCBI_TaxID=10116; ! Rattus norvegicus (Rat)
SX   Female
AG   Adult
CA   Conditionally immortalized cell line
DT   Created: 24-05-19; Last updated: 10-04-25; Version: 12
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RX   PubMed=9528980; DOI=10.1210/endo.139.4.5929;
RA   Sugino N., Zilberstein M., Srivastava R.K., Telleria C.M.,
RA   Nelson S.E., Risk M., Chou J.Y., Gibori G.;
RT   "Establishment and characterization of a simian virus 40-transformed
RT   temperature-sensitive rat luteal cell line.";
RL   Endocrinology 139:1936-1942(1998).
//
RX   PubMed=9564855; DOI=10.1210/endo.139.5.5974;
RA   Telleria C.M., Zhong L.-P., Deb S., Srivastava R.K., Park K.S.,
RA   Sugino N., Park-Sarge O.-K., Gibori G.;
RT   "Differential expression of the estrogen receptors alpha and beta in
RT   the rat corpus luteum of pregnancy: regulation by prolactin and
RT   placental lactogens.";
RL   Endocrinology 139:2432-2442(1998).
//
RX   PubMed=9675014; DOI=10.1095/biolreprod59.1.208;
RA   Sugino N., Telleria C.M., Gibori G.;
RT   "Differential regulation of copper-zinc superoxide dismutase and
RT   manganese superoxide dismutase in the rat corpus luteum: induction of
RT   manganese superoxide dismutase messenger ribonucleic acid by
RT   inflammatory cytokines.";
RL   Biol. Reprod. 59:208-215(1998).
//