ID   BM 2.2.1
AC   CVCL_W999
SY   BM2.2.1; ASL 5; ASL-w17
DR   cancercelllines; CVCL_W999
DR   IARC_TP53; 4803
DR   IARC_TP53; 9738
DR   Wikidata; Q54797439
RX   PubMed=7658501;
RX   PubMed=10022320;
RX   PubMed=10952247;
CC   Population: Caucasian.
CC   Doubling time: 52.8-55.2 hours (Note=At 23th passage) (PubMed=10952247).
CC   Karyotypic information: Has lost chromosome Y.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.His179Leu (c.536A>T); ClinVar=VCV000376608; Zygosity=Homozygous (PubMed=7658501; PubMed=10022320; PubMed=10952247).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
CC   Cell type: Myofibroblast; CL=CL_0000186.
DI   NCIt; C4438; Liver angiosarcoma
DI   ORDO; Orphanet_263413; Angiosarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   60Y
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 19-12-24; Version: 14
//
RX   PubMed=7658501; DOI=10.1093/jnci/87.18.1400;
RA   Trivers G.E., Cawley H.L., DeBenedetti V.M.G., Hollstein M.C.,
RA   Marion M.-J., Bennett W.P., Hoover M.L., Prives C.L., Tamburro C.C.,
RA   Harris C.C.;
RT   "Anti-p53 antibodies in sera of workers occupationally exposed to
RT   vinyl chloride.";
RL   J. Natl. Cancer Inst. 87:1400-1407(1995).
//
RX   PubMed=10022320; DOI=10.1016/S0378-4274(98)00255-0;
RA   Marion M.-J.;
RT   "Critical genes as early warning signs: example of vinyl chloride.";
RL   Toxicol. Lett. 102:603-607(1998).
//
RX   PubMed=10952247; DOI=10.1016/S0168-8278(00)80370-0;
RA   Boivin-Angele S., Pedron S., Bertrand S., Desmouliere A.,
RA   Martel-Planche G., Lefrancois L., Bancel B., Trepo C., Marion M.-J.;
RT   "Establishment and characterization of a spontaneously immortalized
RT   myofibroblast cell line derived from a human liver angiosarcoma.";
RL   J. Hepatol. 33:290-300(2000).
//