AC   CVCL_W974
DR   cancercelllines; CVCL_W974
DR   Wikidata; Q54953220
RX   PubMed=1354203;
RX   PubMed=2535691;
RX   PubMed=6137586;
RX   PubMed=15720811;
RX   PubMed=26342562;
CC   Population: Caucasian.
CC   Characteristics: Intermediate type (I-type) (PubMed=15720811).
CC   Sequence variation: Mutation; HGNC; 427; ALK; Simple; p.Phe1174Leu (c.3522C>A); ClinVar=VCV000217852; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7989; NRAS; Simple; p.Gln61Lys (c.181C>A); ClinVar=VCV000073058; Zygosity=Heterozygous (from parent cell line).
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: Metastatic; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3270; Neuroblastoma
DI   ORDO; Orphanet_635; Neuroblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0531 ! SK-N-SH
SX   Female
AG   4Y
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 05-10-23; Version: 17
RX   PubMed=1354203; DOI=10.1002/ijc.2910520116;
RA   Gross N., Favre S., Beck D., Meyer M.;
RT   "Differentiation-related expression of adhesion molecules and
RT   receptors on human neuroblastoma tissues, cell lines and variants.";
RL   Int. J. Cancer 52:85-91(1992).
RX   PubMed=2535691;
RA   Ciccarone V., Spengler B.A., Meyers M.B., Biedler J.L., Ross R.A.;
RT   "Phenotypic diversification in human neuroblastoma cells: expression
RT   of distinct neural crest lineages.";
RL   Cancer Res. 49:219-225(1989).
RX   PubMed=6137586; DOI=10.1093/jnci/71.4.741;
RA   Ross R.A., Spengler B.A., Biedler J.L.;
RT   "Coordinate morphological and biochemical interconversion of human
RT   neuroblastoma cells.";
RL   J. Natl. Cancer Inst. 71:741-747(1983).
RX   PubMed=15720811; DOI=10.1593/neo.04310;
RA   Walton J.D., Kattan D.R., Thomas S.K., Spengler B.A., Guo H.-F.,
RA   Biedler J.L., Cheung N.-K.V., Ross R.A.;
RT   "Characteristics of stem cells from human neuroblastoma cell lines and
RT   in tumors.";
RL   Neoplasia 6:838-845(2004).
RX   PubMed=26342562; DOI=10.1016/j.scr.2015.08.008;
RA   Ross R.A., Walton J.D., Han D., Guo H.-F., Cheung N.-K.V.;
RT   "A distinct gene expression signature characterizes human
RT   neuroblastoma cancer stem cells.";
RL   Stem Cell Res. 15:419-426(2015).