ID   A07-RM
AC   CVCL_W879
AS   CVCL_LJ86
SY   A07; A07RM; A07.RM; RM
DR   cancercelllines; CVCL_W879
DR   Cosmic; 888983
DR   Cosmic; 928733
DR   GEO; GSM78832
DR   GEO; GSM78833
DR   GEO; GSM78835
DR   GEO; GSM228380
DR   Progenetix; CVCL_W879
DR   Wikidata; Q54606224
RX   PubMed=9354451;
RX   PubMed=15048078;
RX   PubMed=17363583;
RX   PubMed=22383533;
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu2Lys (c.4G>A); Zygosity=Unspecified (PubMed=9354451; PubMed=17363583).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gly12Ser (c.34G>A); ClinVar=VCV000177778; Zygosity=Heterozygous (PubMed=15048078; PubMed=17363583; PubMed=22383533).
CC   Sequence variation: Mutation; HGNC; HGNC:7989; NRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000013900; Zygosity=Unspecified (PubMed=15048078; PubMed=17363583).
CC   Omics: Variations; CNV analysis.
CC   Omics: Variations; SNP array analysis.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 10-04-25; Version: 15
//
RX   PubMed=9354451;
RA   Castellano, Marina
RA   Pollock, Pamela M.
RA   Walters, Marilyn K.
RA   Sparrow, Louise E.
RA   Down, Louise M.
RA   Gabrielli, Brian G.
RA   Parsons, Peter G.
RA   Hayward, Nicholas K.
RT   "CDKN2A/p16 is inactivated in most melanoma cell lines.";
RL   Cancer Res. 57:4868-4875(1997).
//
RX   PubMed=17363583; DOI=10.1158/0008-5472.CAN-06-4152;
RA   Stark, Mitchell S.
RA   Hayward, Nicholas K.
RT   "Genome-wide loss of heterozygosity and copy number analysis in
RT   melanoma using high-density single-nucleotide polymorphism arrays.";
RL   Cancer Res. 67:2632-2642(2007).
//
RX   PubMed=15048078; DOI=10.1038/sj.onc.1207563;
RA   Pavey, Sandra
RA   Johansson, Peter
RA   Packer, Leisl
RA   Taylor, Jennifer
RA   Stark, Mitchell S.
RA   Pollock, Pamela M.
RA   Walker, Graeme J.
RA   Boyle, Glen M.
RA   Harper, Ursula
RA   Cozzi, Sarah-Jane
RA   Hansen, Katherine
RA   Yudt, Laura
RA   Schmidt, Chris
RA   Hersey, Peter
RA   Ellem, Kay Adrian Oswald
RA   O'Rourke, Michael G.E.
RA   Parsons, Peter G.
RA   Meltzer, Paul S.
RA   Ringner, Markus
RA   Hayward, Nicholas K.
RT   "Microarray expression profiling in melanoma reveals a BRAF mutation
RT   signature.";
RL   Oncogene 23:4060-4067(2004).
//
RX   PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676;
RA   Dutton-Regester, Ken
RA   Irwin, Darryl
RA   Hunt, Priscilla
RA   Aoude, Lauren G.
RA   Tembe, Varsha
RA   Pupo, Gulietta M.
RA   Lanagan, Cathy
RA   Carter, Candace D.
RA   O'Connor, Linda
RA   O'Rourke, Michael
RA   Scolyer, Richard Anthony
RA   Mann, Graham J.
RA   Schmidt, Christopher W.
RA   Herington, Adrian
RA   Hayward, Nicholas K.
RT   "A high-throughput panel for identifying clinically relevant mutation
RT   profiles in melanoma.";
RL   Mol. Cancer Ther. 11:888-897(2012).
//