ID   DS179
AC   CVCL_W747
SY   DS 179
DR   cancercelllines; CVCL_W747
DR   Cosmic; 2808225
DR   Wikidata; Q54831439
RX   PubMed=1325212;
RX   PubMed=6286763;
RX   PubMed=8220424;
RX   PubMed=8344493;
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg273Cys (c.817C>T); ClinVar=VCV000043594; Zygosity=Homozygous (PubMed=8344493).
DI   NCIt; C3457; B-cell non-Hodgkin lymphoma
DI   ORDO; Orphanet_171915; B-cell non-Hodgkin lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
CA   Cancer cell line
DT   Created: 17-07-14; Last updated: 05-10-23; Version: 14
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RX   PubMed=1325212; DOI=10.1182/blood.V80.5.1289.1289;
RA   Benjamin D., Knobloch T.J., Dayton M.A.;
RT   "Human B-cell interleukin-10: B-cell lines derived from patients with
RT   acquired immunodeficiency syndrome and Burkitt's lymphoma
RT   constitutively secrete large quantities of interleukin-10.";
RL   Blood 80:1289-1298(1992).
//
RX   PubMed=6286763; DOI=10.4049/jimmunol.129.3.1336;
RA   Benjamin D., Magrath I.T., Maguire R.T., Janus C., Todd H.D.,
RA   Parsons R.G.;
RT   "Immunoglobulin secretion by cell lines derived from African and
RT   American undifferentiated lymphomas of Burkitt's and non-Burkitt's
RT   type.";
RL   J. Immunol. 129:1336-1342(1982).
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RX   PubMed=8220424; DOI=10.1038/ng0993-56;
RA   Bhatia K.G., Huppi K., Spangler G., Siwarski D., Iyer R., Magrath I.T.;
RT   "Point mutations in the c-Myc transactivation domain are common in
RT   Burkitt's lymphoma and mouse plasmacytomas.";
RL   Nat. Genet. 5:56-61(1993).
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RX   PubMed=8344493; DOI=10.1096/fasebj.7.10.8344493;
RA   Bhatia K.G., Goldschmidts W., Gutierrez M.I., Gaidano G., Dalla-Favera R.,
RA   Magrath I.T.;
RT   "Hemi- or homozygosity: a requirement for some but not other p53
RT   mutant proteins to accumulate and exert a pathogenetic effect.";
RL   FASEB J. 7:951-956(1993).
//