ID   KH88 C2F8
AC   CVCL_W721
SY   KH88-C2F8; KH88 subclone C2F8; C2F8
DR   Cosmic; 949098
DR   Wikidata; Q54899865
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8289484;
RX   PubMed=9644295;
RX   PubMed=10071072;
RX   PubMed=10576511;
CC   Population: Japanese.
CC   Doubling time: 20-26 hours (PubMed=8289484).
CC   Sequence variation: Gene fusion; HGNC; HGNC:76; ABL1 + HGNC; HGNC:1014; BCR; Name(s)=BCR-ABL1, BCR-ABL; Note=BCR exon 14 fused to ABL1 exon 2 (b3a2 transcript) (PubMed=10071072; PubMed=10576511).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C3174; Chronic myelogenous leukemia, BCR-ABL1 positive
DI   ORDO; Orphanet_521; Chronic myeloid leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_G364 ! KH88
SX   Male
AG   69Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 19-12-24; Version: 13
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=8289484;
RA   Furukawa T., Koike T., Ying W., Kishi K., Aoki S., Gotoh T.,
RA   Hashimoto S., Saitoh H., Hanano M., Shinada S., Moriyama Y.,
RA   Takahashi M., Endo Y., Okano H., Maekawa T., Abe T., Shibata A.;
RT   "Establishment of a new cell line with the characteristics of a
RT   multipotential progenitor from a patient with chronic myelogenous
RT   leukemia in early erythroblastic crisis.";
RL   Leukemia 8:171-180(1994).
//
RX   PubMed=9644295; DOI=10.1159/000040837;
RA   Kaneko H., Horiike S., Sasai Y., Iwai T., Nakao M., Yokota S.,
RA   Taniwaki M., Kashima K., Misawa S.-i.;
RT   "Rare alteration of genomic structure or expression of the DPC4 gene
RT   in myelogenous leukemias.";
RL   Acta Haematol. 99:187-190(1998).
//
RX   PubMed=10071072; DOI=10.1016/S0145-2126(98)00171-4;
RA   Drexler H.G., MacLeod R.A.F., Uphoff C.C.;
RT   "Leukemia cell lines: in vitro models for the study of Philadelphia
RT   chromosome-positive leukemia.";
RL   Leuk. Res. 23:207-215(1999).
//
RX   PubMed=10576511; DOI=10.1016/S0145-2126(99)00131-9;
RA   Uphoff C.C., Habig S., Fombonne S., Matsuo Y., Drexler H.G.;
RT   "ABL-BCR expression in BCR-ABL-positive human leukemia cell lines.";
RL   Leuk. Res. 23:1055-1060(1999).
//