ID   SBC-2 [Human SCLC]
AC   CVCL_W531
DR   CLO; CLO_0008951
DR   cancercelllines; CVCL_W531
DR   Cell_Model_Passport; SIDM00366
DR   GEO; GSM17312
DR   GEO; GSM827568
DR   JCRB; JCRB0817
DR   LINCS_LDP; LCL-1866
DR   Progenetix; CVCL_W531
DR   Wikidata; Q54952165
RX   CelloPub=CLPUB00132;
RX   DOI=10.4044/joma1947.104.9-10_905;
RX   PubMed=8286010;
RX   PubMed=9290701;
RX   PubMed=9413215;
RX   PubMed=10358721;
RX   PubMed=10628341;
RX   PubMed=15016488;
RX   PubMed=20215515;
RX   PubMed=22399608;
CC   Problematic cell line: Possibly misidentified/contaminated. Shown to be identical to SBC-1 (JCRB web site and STR profile).
CC   Population: Japanese.
CC   Doubling time: 33.8 hours (PubMed=8286010).
CC   Omics: SNP array analysis.
CC   Omics: Transcriptome analysis by microarray.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
ST   Source(s): JCRB=JCRB0817
ST   Amelogenin: X
ST   CSF1PO: 10,12
ST   D13S317: 12
ST   D16S539: 9
ST   D5S818: 9,11
ST   D7S820: 11,12
ST   TH01: 8,9
ST   TPOX: 8
ST   vWA: 14,17
DI   NCIt; C4917; Lung small cell carcinoma
DI   ORDO; Orphanet_70573; Small cell lung cancer
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
OI   CVCL_1676 ! SBC-1
SX   Male
AG   46Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 02-05-24; Version: 22
//
RX   CelloPub=CLPUB00132;
RA   Kishimoto N., Ohnoshi T., Hiraki S., Miyake K., Ozawa S., Tamura T.,
RA   Numata T., Kawahara S., Tamura R., Miyamoto H., Nishii K., Kimura I.;
RT   "Establishment and characterization of five cell lines from human
RT   small cell carcinoma of the lung.";
RL   Nihon Haigan Gakkai 24:644-644(1984).
//
RX   DOI=10.4044/joma1947.104.9-10_905;
RA   Kishimoto N.;
RT   "Studies on cell biology and chemotherapy of lung cancer using tissue
RT   culture techniques. Part 2. Biological characteristics of five newly
RT   established small cell lung cancer cell lines.";
RL   Okayama Igakkai Zasshi 104:905-913(1992).
//
RX   PubMed=8286010;
RA   Kiura K., Watarai S., Shibayama T., Ohnoshi T., Kimura I., Yasuda T.;
RT   "Inhibitory effects of cholera toxin on in vitro growth of human lung
RT   cancer cell lines.";
RL   Anticancer Drug Des. 8:417-428(1993).
//
RX   PubMed=9290701; DOI=10.1002/(SICI)1098-2744(199708)19:4<243::AID-MC5>3.0.CO;2-D;
RA   Jia L.-Q., Osada M., Ishioka C., Gamo M., Ikawa S., Suzuki T.,
RA   Shimodaira H., Niitani T., Kudo T., Akiyama M., Kimura N., Matsuo M.,
RA   Mizusawa H., Tanaka N., Koyama H., Namba M., Kanamaru R., Kuroki T.;
RT   "Screening the p53 status of human cell lines using a yeast functional
RT   assay.";
RL   Mol. Carcinog. 19:243-253(1997).
//
RX   PubMed=9413215;
RA   Yamane H., Kiura K., Tabata M., Bessho A., Tsuchida T., Motoda K.,
RA   Hiraki A., Ueoka H., Harada M.;
RT   "Small cell lung cancer can express CD34 antigen.";
RL   Anticancer Res. 17:3627-3632(1997).
//
RX   PubMed=10358721; DOI=10.18926/AMO/31626;
RA   Matsushita A., Tabata M., Ueoka H., Kiura K., Shibayama T., Aoe K.,
RA   Kohara H., Harada M.;
RT   "Establishment of a drug sensitivity panel using human lung cancer
RT   cell lines.";
RL   Acta Med. Okayama 53:67-75(1999).
//
RX   PubMed=10628341;
RA   Ikubo S., Takigawa N., Ueoka H., Kiura K., Tabata M., Shibayama T.,
RA   Chikamori M., Aoe K., Matsushita A., Harada M.;
RT   "In vitro evaluation of antimicrotubule agents in human small-cell
RT   lung cancer cell lines.";
RL   Anticancer Res. 19:3985-3988(1999).
//
RX   PubMed=15016488; DOI=10.1016/S0140-6736(04)15693-6;
RA   Jones M.H., Virtanen C., Honjoh D., Miyoshi T., Satoh Y., Okumura S.,
RA   Nakagawa K., Nomura H., Ishikawa Y.;
RT   "Two prognostically significant subtypes of high-grade lung
RT   neuroendocrine tumours independent of small-cell and large-cell
RT   neuroendocrine carcinomas identified by gene expression profiles.";
RL   Lancet 363:775-781(2004).
//
RX   PubMed=20215515; DOI=10.1158/0008-5472.CAN-09-3458; PMCID=PMC2881662;
RA   Rothenberg S.M., Mohapatra G., Rivera M.N., Winokur D., Greninger P.,
RA   Nitta M., Sadow P.M., Sooriyakumar G., Brannigan B.W., Ulman M.J.,
RA   Perera R.M., Wang R., Tam A., Ma X.-J., Erlander M., Sgroi D.C.,
RA   Rocco J.W., Lingen M.W., Cohen E.E.W., Louis D.N., Settleman J.,
RA   Haber D.A.;
RT   "A genome-wide screen for microdeletions reveals disruption of
RT   polarity complex genes in diverse human cancers.";
RL   Cancer Res. 70:2158-2164(2010).
//
RX   PubMed=22399608;
RA   Tsuchida T., Yamane H., Ochi N., Tabayashi T., Hiraki A., Nogami N.,
RA   Takigawa N., Kiura K., Tanimoto M.;
RT   "Cytotoxicity of activated natural killer cells and expression of
RT   adhesion molecules in small-cell lung cancer.";
RL   Anticancer Res. 32:887-892(2012).
//