ID   W-ES
AC   CVCL_W528
DR   cancercelllines; CVCL_W528
DR   Cosmic; 1085908
DR   Cosmic; 1381110
DR   IARC_TP53; 1275
DR   Wikidata; Q54993449
RX   PubMed=2486606;
RX   PubMed=2731119;
RX   PubMed=8221663;
RX   PubMed=9738976;
RX   PubMed=12054564;
CC   Population: Japanese.
CC   Doubling time: 35 hours (PubMed=2486606).
CC   Sequence variation: Gene fusion; HGNC; HGNC:3446; ERG + HGNC; HGNC:3508; EWSR1; Name(s)=EWSR1-ERG, EWS-ERG (PubMed=9738976).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Cys176Phe (c.527G>T); ClinVar=VCV000376569; Zygosity=Unspecified (PubMed=8221663).
DI   NCIt; C4817; Ewing sarcoma
DI   ORDO; Orphanet_319; Ewing sarcoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   14Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 19-12-24; Version: 18
//
RX   PubMed=2486606;
RA   Fujii Y., Nakagawa Y., Hongo T., Igarashi Y., Naito Y., Maeda M.;
RT   "Cell line of small round cell tumor originating in the chest wall:
RT   W-ES.";
RL   Hum. Cell 2:190-191(1989).
//
RX   PubMed=2731119; DOI=10.1002/1097-0142(19890701)64:1<43::AID-CNCR2820640109>3.0.CO;2-F;
RA   Fujii Y., Hongo T., Nakagawa Y., Nasuda K., Mizuno Y., Igarashi Y.,
RA   Naito Y., Maeda M.;
RT   "Cell culture of small round cell tumor originating in the
RT   thoracopulmonary region. Evidence for derivation from a primitive
RT   pluripotent cell.";
RL   Cancer 64:43-51(1989).
//
RX   PubMed=8221663;
RA   Komuro H., Hayashi Y., Kawamura M., Hayashi K., Kaneko Y.,
RA   Kamoshita S., Hanada R., Yamamoto K., Hongo T., Yamada M., Tsuchida Y.;
RT   "Mutations of the p53 gene are involved in Ewing's sarcomas but not in
RT   neuroblastomas.";
RL   Cancer Res. 53:5284-5288(1993).
//
RX   PubMed=9738976; DOI=10.1111/j.1349-7006.1998.tb03274.x; PMCID=PMC5921883;
RA   Urano F., Umezawa A., Yabe H., Hong W., Yoshida K., Fujinaga K.,
RA   Hata J.-i.;
RT   "Molecular analysis of Ewing's sarcoma: another fusion gene, EWS-E1AF,
RT   available for diagnosis.";
RL   Jpn. J. Cancer Res. 89:703-711(1998).
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RX   PubMed=12054564; DOI=10.1016/S0006-291X(02)00129-8;
RA   Yabe H., Fukuma M., Urano F., Yoshida K., Kato S., Toyama Y., Hata J.-i.,
RA   Umezawa A.;
RT   "Lack of matrix metalloproteinase (MMP)-1 and -3 expression in Ewing
RT   sarcoma may be due to loss of accessibility of the MMP regulatory
RT   element to the specific fusion protein in vivo.";
RL   Biochem. Biophys. Res. Commun. 293:61-71(2002).
//