ID   HAK-2
AC   CVCL_W445
DR   Wikidata; Q54872380
RX   PubMed=9023415;
RX   PubMed=9178645;
RX   PubMed=9436038;
RX   PubMed=10347112;
CC   Population: Japanese.
CC   Doubling time: 36.8 hours (Note=At 47th passage) (PubMed=9436038).
CC   HLA typing: A*02:01,11:01; B*38:01; C*12:03; DQA1*01:02; DQB1*06:04; DRB1*13:02 (PubMed=9178645).
CC   Derived from site: In situ; Liver; UBERON=UBERON_0002107.
DI   NCIt; C7956; Adult hepatocellular carcinoma
DI   ORDO; Orphanet_210159; Adult hepatocellular carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   57Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 29-06-23; Version: 11
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RX   PubMed=9023415; DOI=10.1006/cimm.1996.1062;
RA   Seki N., Hoshino T., Kikuchi M., Hayashi A., Itoh K.;
RT   "HLA-A locus-restricted and tumor-specific CTLs in tumor-infiltrating
RT   lymphocytes of patients with non-small cell lung cancer.";
RL   Cell. Immunol. 175:101-110(1997).
//
RX   PubMed=9178645; DOI=10.1006/cimm.1997.1108;
RA   Nakao M., Sata M., Saitsu H., Yutani S., Kawamoto M., Kojiro M.,
RA   Itoh K.;
RT   "CD4+ hepatic cancer-specific cytotoxic T lymphocytes in patients with
RT   hepatocellular carcinoma.";
RL   Cell. Immunol. 177:176-181(1997).
//
RX   PubMed=9436038;
RA   Haramaki M., Yano H., Iemura A., Momosaki S., Ogasawara S., Inoue M.,
RA   Yamaguchi R., Kusaba A., Utsunomiya I., Kojiro M.;
RT   "A new human hepatocellular carcinoma cell line (HAK-2) forms various
RT   structures in collagen gel matrices.";
RL   Hum. Cell 10:183-192(1997).
//
RX   PubMed=10347112; DOI=10.1002/hep.510290624;
RA   Yano H., Iemura A., Haramaki M., Ogasawara S., Takayama A., Akiba J.,
RA   Kojiro M.;
RT   "Interferon alfa receptor expression and growth inhibition by
RT   interferon alfa in human liver cancer cell lines.";
RL   Hepatology 29:1708-1717(1999).
//