ID   EIIL
AC   CVCL_W441
DR   cancercelllines; CVCL_W441
DR   Wikidata; Q54832166
RX   PubMed=7699285;
RX   PubMed=8718550;
RX   PubMed=10381137;
CC   Population: Japanese.
CC   Characteristics: Estrogen-independent (PubMed=7699285).
CC   Sequence variation: Mutation; HGNC; HGNC:8979; PIK3R1; Simple; p.Leu570Pro (c.1709T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9177; POLE; Simple; p.Pro102Ser (c.304C>T); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9177; POLE; Simple; p.Asn751fs (c.2252delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Glu288fs*3 (c.863delA); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Thr319fs*1 (c.950_953delTACT) (p.VL317fs) (V317fs*3); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Asp49His (c.145G>C); ClinVar=VCV000135948; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met246Val (c.736A>G); ClinVar=VCV000100815; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Endometrium; UBERON=UBERON_0001295.
DI   NCIt; C40145; Type I endometrial adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2529 ! Ishikawa
SX   Female
AG   39Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 19-12-24; Version: 11
//
RX   PubMed=7699285;
RA   Sakamoto H., Deng X.-H., Shirakawa T., Ige S., Ohtani K., Saitoh A.,
RA   Takami M., Takami T., Satoh K.;
RT   "Establishment of metastatic sub-clone from estrogen independent
RT   Ishikawa cells and its characterization in vitro and in vivo.";
RL   Nihon Sanka Fujinka Gakkai Zasshi 47:249-256(1995).
//
RX   PubMed=8718550;
RA   Shirakawa T., Sakamoto H., Satoh K.;
RT   "Separation and characterization of estrogen independent endometrial
RT   cancer cell line originated from Ishikawa strain.";
RL   Nihon Sanka Fujinka Gakkai Zasshi 48:139-146(1996).
//
RX   PubMed=10381137; DOI=10.1016/S0304-3835(98)00270-5;
RA   Ohta H., Sakamoto H., Satoh K.;
RT   "In vitro effects of gonadotropin-releasing hormone (GnRH) analogue on
RT   cancer cell sensitivity to cis-platinum.";
RL   Cancer Lett. 134:111-118(1998).
//