ID   KOPN-49
AC   CVCL_W276
SY   KOPN49
DR   IARC_TP53; 2683
DR   Wikidata; Q54900310
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RX   PubMed=8289498;
RX   PubMed=10360377;
RX   PubMed=29786757;
RX   PubMed=35124168;
CC   Population: Japanese.
CC   Sequence variation: Gene fusion; HGNC; HGNC:14281; CRLF2 + HGNC; HGNC:5477; IGH; Name(s)=CRLF-IgH (PubMed=29786757).
CC   Sequence variation: Mutation; HGNC; HGNC:6192; JAK2; Simple; p.Arg683Gly (c.2047A>G); ClinVar=VCV000375951; Zygosity=Unspecified (PubMed=29786757).
CC   Sequence variation: Mutation; HGNC; HGNC:6407; KRAS; Simple; p.Gly13Asp (c.38G>A); ClinVar=VCV000012580; Zygosity=Unspecified (PubMed=29786757).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282fs (c.845delGinsCCC); Zygosity=Hemizygous (PubMed=8289498).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   ORDO; Orphanet_99860; Precursor B-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   12Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 19-12-24; Version: 14
//
RX   DOI=10.1016/B978-0-12-221970-2.50457-5;
RA   Drexler H.G.;
RT   "The leukemia-lymphoma cell line factsbook.";
RL   (In book) ISBN 9780122219702; pp.1-733; Academic Press; London; United Kingdom (2001).
//
RX   PubMed=8289498;
RA   Wada H., Asada M., Nakazawa S., Itoh H., Kobayashi Y., Inoue T.,
RA   Fukumuro K., Chan L.C., Sugita K., Hanada R., Akuta N., Kobayashi N.,
RA   Mizutani S.;
RT   "Clonal expansion of p53 mutant cells in leukemia progression in
RT   vitro.";
RL   Leukemia 8:53-59(1994).
//
RX   PubMed=10360377; DOI=10.1038/sj.leu.2401437;
RA   Nakamura M., Sugita K., Inukai T., Goi K., Iijima K., Tezuka T.,
RA   Kojika S., Shiraishi K., Miyamoto N., Karakida N., Kagami K.,
RA   Koyama-Okazaki T., Mori T., Nakazawa S.;
RT   "p16/MTS1/INK4A gene is frequently inactivated by hypermethylation in
RT   childhood acute lymphoblastic leukemia with 11q23 translocation.";
RL   Leukemia 13:884-890(1999).
//
RX   PubMed=29786757; DOI=10.1007/s12185-018-2474-7;
RA   Tomoyasu C., Imamura T., Tomii T., Yano M., Asai D., Goto H.,
RA   Shimada A., Sanada M., Iwamoto S., Takita J., Minegishi M., Inukai T.,
RA   Sugita K., Hosoi H.;
RT   "Copy number abnormality of acute lymphoblastic leukemia cell lines
RT   based on their genetic subtypes.";
RL   Int. J. Hematol. 108:312-318(2018).
//
RX   PubMed=35124168; DOI=10.1016/j.jsbmb.2022.106068;
RA   Tamai M., Kasai S., Akahane K., Thu T.N., Kagami K., Komatsu C.,
RA   Abe M., Watanabe A., Goi K., Miyake K., Inaba T., Takita J., Goto H.,
RA   Minegishi M., Iwamoto S., Sugita K., Inukai T.;
RT   "Glucocorticoid receptor gene mutations confer glucocorticoid
RT   resistance in B-cell precursor acute lymphoblastic leukemia.";
RL   J. Steroid Biochem. Mol. Biol. 218:106068.1-106068.12(2022).
//