ID   BLaER1
AC   CVCL_VQ57
SY   B cell Leukemia C/EBPalphaER clone 1
DR   Millipore; SCC165
DR   Wikidata; Q93427919
RX   PubMed=23545498;
RX   PubMed=28494875;
CC   Population: Caucasian.
CC   Characteristics: Can efficiently be convert into cells exhibiting increased adherent, phagocytic and quiescent properties with a transcriptome resembling normal macrophages.
CC   Characteristics: Transfected with the retrovirus vector C/EBPaER-GFP which consist of CEBPA fused with the estrogen receptor hormone binding domain and GFP.
CC   Sequence variation: Gene fusion; HGNC; 8632; PBX1 + HGNC; 11633; TCF3; Name(s)=TCF3-PBX1; E2A-PBX1 (from parent cell line).
CC   Transfected with: HGNC; 1833; CEBPA.
CC   Transfected with: HGNC; 3467; ESR1 (ligand-binding domain).
CC   Transfected with: UniProtKB; P42212; GFP (with p.Phe64Leu, p.Ser65Thr and p.His231Leu = EGFP).
CC   Caution: Was originally (PubMed=23545498) described as originating from the Seraphina cell line (Cellosaurus=CVCL_M646) but was later (PubMed=28494875) shown to derive from RCH-ACV.
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
ST   Source(s): Millipore=SCC165
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 9,14
ST   D16S539: 11
ST   D18S51: 13,16
ST   D21S11: 29,31.2
ST   D3S1358: 15
ST   D5S818: 11,12
ST   D7S820: 10,11
ST   D8S1179: 13,15
ST   FGA: 23,26
ST   Penta D: 8.4,10
ST   Penta E: 7,11
ST   TH01: 6,8
ST   TPOX: 8,11
ST   vWA: 16,17
DI   NCIt; C9140; Childhood B acute lymphoblastic leukemia
DI   NCIt; C80347; B acute lymphoblastic leukemia with t(1;19)(q23;p13.3) E2A-PBX1 (TCF3-PBX1)
DI   ORDO; Orphanet_585956; B-lymphoblastic leukemia/lymphoma with t(1;19)(q23;p13.3)
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_1851 ! RCH-ACV
SX   Female
AG   8Y
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 02-05-24; Version: 12
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RX   PubMed=23545498; DOI=10.1016/j.celrep.2013.03.003;
RA   Rapino F., Robles E.F., Richter-Larrea J.A., Kallin E.M.,
RA   Martinez-Climent J.A., Graf T.;
RT   "C/EBPalpha induces highly efficient macrophage transdifferentiation
RT   of B lymphoma and leukemia cell lines and impairs their
RT   tumorigenicity.";
RL   Cell Rep. 3:1153-1163(2013).
//
RX   PubMed=28494875; DOI=10.1016/j.celrep.2017.04.072;
RA   Rapino F., Robles E.F., Richter-Larrea J.A., Kallin E.M.,
RA   Martinez-Climent J.A., Graf T.;
RT   "Erratum: C/EBPalpha induces highly efficient macrophage
RT   transdifferentiation of B lymphoma and leukemia cell lines and impairs
RT   their tumorigenicity.";
RL   Cell Rep. 19:1281-1281(2017).
//