ID   ATL-48T
AC   CVCL_VQ16
SY   ATL-48T(+)
DR   RCB; RCB3535
DR   RCB; RCB3570
DR   Wikidata; Q93326745
RX   PubMed=2889484;
RX   PubMed=10706122;
RX   PubMed=16242045;
RX   PubMed=32210945;
CC   Population: Japanese.
CC   Characteristics: IL2 dependent.
CC   Transformant: NCBI_TaxID; 11908; Human T-lymphotropic virus 1 (HTLV-1).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C3184; Adult T-cell leukemia/lymphoma
DI   ORDO; Orphanet_86875; Adult T-cell leukemia/lymphoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Adult
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 29-06-23; Version: 9
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RX   PubMed=2889484; DOI=10.1182/blood.V70.5.1407.1407;
RA   Maeda M., Arima N., Daitoku Y., Kashihara M., Okamoto H., Uchiyama T.,
RA   Shirono K., Matsuoka M., Hattori T., Takatsuki K., Ikuta K.,
RA   Shimizu A., Honjo T., Yodoi J.;
RT   "Evidence for the interleukin-2 dependent expansion of leukemic cells
RT   in adult T cell leukemia.";
RL   Blood 70:1407-1411(1987).
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RX   PubMed=10706122;
RA   Nosaka K., Maeda M., Tamiya S., Sakai T., Mitsuya H., Matsuoka M.;
RT   "Increasing methylation of the CDKN2A gene is associated with the
RT   progression of adult T-cell leukemia.";
RL   Cancer Res. 60:1043-1048(2000).
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RX   PubMed=16242045; DOI=10.1186/1742-4690-2-64;
RA   Taniguchi Y., Nosaka K., Yasunaga J.-i., Maeda M., Mueller N.,
RA   Okayama A., Matsuoka M.;
RT   "Silencing of human T-cell leukemia virus type I gene transcription by
RT   epigenetic mechanisms.";
RL   Retrovirology 2:64.1-64.16(2005).
//
RX   PubMed=32210945; DOI=10.3389/fmicb.2020.00356;
RA   Maeda M., Tanabe-Shibuya J., Miyazato P., Masutani H., Yasunaga J.-i.,
RA   Usami K., Shimizu A., Matsuoka M.;
RT   "IL-2/IL-2 receptor pathway plays a crucial role in the growth and
RT   malignant transformation of HTLV-1-infected T cells to develop adult
RT   T-cell leukemia.";
RL   Front. Microbiol. 11:356.1-356.17(2020).
//