ID   CUTC61
AC   CVCL_VM62
DR   cancercelllines; CVCL_VM62
DR   Wikidata; Q93460554
RX   PubMed=30733375;
RX   PubMed=30737244;
CC   Doubling time: 29 hours (PubMed=30733375).
CC   Sequence variation: Mutation; HGNC; HGNC:5173; HRAS; Simple; p.Gln61Arg (c.182A>G); ClinVar=VCV000160364; Zygosity=Heterozygous (PubMed=30733375; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Heterozygous; Note=In promoter (PubMed=30733375; PubMed=30737244).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.375+1G>A; ClinVar=VCV000634702; Zygosity=Homozygous; Note=Splice donor mutation (PubMed=30733375; PubMed=30737244).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: In situ; Thyroid gland; UBERON=UBERON_0002046.
ST   Source(s): PubMed=30733375; PubMed=30737244
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 11,12
ST   D16S539: 11,13
ST   D18S51: 14,19
ST   D21S11: 28,30
ST   D3S1358: 14,15
ST   D5S818: 10,12
ST   D7S820: 8,10
ST   D8S1179: 12,15
ST   FGA: 24,25
ST   TH01: 8,9
ST   TPOX: 8
ST   vWA: 17,18
DI   NCIt; C8054; Thyroid gland follicular carcinoma
DI   ORDO; Orphanet_146; Differentiated thyroid carcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   72Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 10-04-25; Version: 14
//
RX   PubMed=30733375; DOI=10.1158/1541-7786.MCR-18-1026; PMCID=PMC6711777;
RA   Schweppe R.E., Pozdeyev N., Pike L.A., Korch C.T., Zhou Q., Sams S.B.,
RA   Sharma V., Pugazhenthi U., Raeburn C.D., Albuja-Cruz M.B., Reigan P.,
RA   LaBarbera D.V., Landa-Lopez I., Knauf J.A., Fagin J.A., Haugen B.R.;
RT   "Establishment and characterization of four novel thyroid cancer cell
RT   lines and PDX models expressing the RET/PTC1 rearrangement, BRAFV600E,
RT   or RASQ61R as drivers.";
RL   Mol. Cancer Res. 17:1036-1048(2019).
//
RX   PubMed=30737244; DOI=10.1158/1078-0432.CCR-18-2953; PMCID=PMC6522280;
RA   Landa I., Pozdeyev N., Korch C.T., Marlow L.A., Smallridge R.C.,
RA   Copland J.A. 3rd, Henderson Y.C., Lai S.Y., Clayman G.L., Onoda N.,
RA   Tan A.-C., Garcia-Rendueles M.E.R., Knauf J.A., Haugen B.R.,
RA   Fagin J.A., Schweppe R.E.;
RT   "Comprehensive genetic characterization of human thyroid cancer cell
RT   lines: a validated panel for preclinical studies.";
RL   Clin. Cancer Res. 25:3141-3151(2019).
//