ID   TSCCa
AC   CVCL_VL15
SY   TSCCA
DR   BTO; BTO:0006082
DR   CCTCC; GDC0184
DR   Wikidata; Q98133629
RX   PubMed=10779629;
RX   PubMed=12149736;
RX   PubMed=15929393;
RX   PubMed=26116706;
RX   PubMed=28107433;
WW   https://iclac.org/wp-content/uploads/Cross-Contaminations_v12_distribution.xlsx
CC   Problematic cell line: Contaminated. Shown to be a HeLa derivative (PubMed=26116706; PubMed=28107433). Originally thought to originate from a tongue squamous cell carcinoma.
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00579.
CC   Population: African American.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
ST   Source(s): PubMed=26116706; PubMed=28107433
ST   Amelogenin: X
ST   CSF1PO: 9,10
ST   D12S391: 20,25
ST   D13S317: 12,13.3
ST   D16S539: 9,10
ST   D18S51: 16
ST   D19S433: 13,14
ST   D21S11: 27,28
ST   D2S1338: 17
ST   D2S441: 10,11
ST   D3S1358: 15,18
ST   D5S818: 11,12
ST   D7S820: 8,12
ST   D8S1179: 12,13
ST   FGA: 21
ST   Penta D: 8,13 (PubMed=28107433)
ST   Penta D: 8,15 (PubMed=26116706)
ST   Penta E: 7,17
ST   TH01: 7
ST   TPOX: 8,12
ST   vWA: 16,18
DI   NCIt; C27677; Human papillomavirus-related cervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0030 ! HeLa
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 05-10-23; Version: 9
//
RX   PubMed=10779629; DOI=10.1016/S0304-3835(00)00389-X;
RA   Lee Y.-J., Liao P.-H., Chen W.-K., Yang C.-Y.;
RT   "Preferential cytotoxicity of caffeic acid phenethyl ester analogues
RT   on oral cancer cells.";
RL   Cancer Lett. 153:51-56(2000).
//
RX   PubMed=12149736; DOI=10.1053/joms.2002.33860;
RA   Shang Z.-J., Li J.-R., Li Z.-B.;
RT   "Effects of exogenous nitric oxide on oral squamous cell carcinoma: an
RT   in vitro study.";
RL   J. Oral Maxillofac. Surg. 60:905-910(2002).
//
RX   PubMed=15929393;
RA   Huang C.-R., Lin S.-S., Chou M.-Y., Ho C.-C., Wang L., Lee Y.-L.,
RA   Chen C.-S., Yang C.-C.;
RT   "Demonstration of different modes of cell death upon herpes simplex
RT   virus 1 infection in different types of oral cells.";
RL   Acta Virol. 49:7-15(2005).
//
RX   PubMed=26116706; DOI=10.1096/fj.14-266718;
RA   Ye F., Chen C.-G., Qin J., Liu J., Zheng C.-Y.;
RT   "Genetic profiling reveals an alarming rate of cross-contamination
RT   among human cell lines used in China.";
RL   FASEB J. 29:4268-4272(2015).
//
RX   PubMed=28107433; DOI=10.1371/journal.pone.0170384;
RA   Huang Y.-Q., Liu Y.-H., Zheng C.-Y., Shen C.;
RT   "Investigation of cross-contamination and misidentification of 278
RT   widely used tumor cell lines.";
RL   PLoS ONE 12:E0170384-E0170384(2017).
//