ID   ORL-195
AC   CVCL_VJ43
SY   ORL-195T; 195T
DR   BioGRID_ORCS_Cell_line; 1277
DR   cancercelllines; CVCL_VJ43
DR   Cell_Model_Passport; SIDM01999
DR   Cosmic; 2531647
DR   Cosmic; 2559743
DR   Wikidata; Q98128363
RX   PubMed=24224046;
RX   PubMed=27050151;
RX   PubMed=32990596;
CC   Population: Indian.
CC   Sequence variation: Mutation; HGNC; HGNC:1101; BRCA2; Simple; p.Thr3033Asnfs*11 (c.9097dupA); ClinVar=VCV000038208; Zygosity=Unspecified (PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met169Ilefs*4 (c.507delG); Zygosity=Unspecified (PubMed=24224046; PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Met237Lys (c.710T>A); ClinVar=VCV000376636; Zygosity=Unspecified (PubMed=24224046; PubMed=27050151).
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Oral cavity, buccal mucosa; UBERON=UBERON_0006956.
ST   Source(s): PubMed=27050151
ST   Amelogenin: X
ST   CSF1PO: 11,12
ST   D13S317: 11,12
ST   D16S539: 11,12
ST   D18S51: 13
ST   D19S433: 13,15.2
ST   D21S11: 29,31.2
ST   D2S1338: 19
ST   D3S1358: 17
ST   D5S818: 11,16
ST   D7S820: 10,11
ST   D8S1179: 14,16
ST   FGA: 24
ST   TH01: 6,9
ST   TPOX: 8,9
ST   vWA: 16,18
DI   NCIt; C4040; Buccal mucosa squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Female
AG   61Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 10-04-25; Version: 12
//
RX   PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115;
RA   Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A.,
RA   Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.;
RT   "Common oncogenic mutations are infrequent in oral squamous cell
RT   carcinoma of Asian origin.";
RL   PLoS ONE 8:e80229.1-e80229.12(2013).
//
RX   PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689;
RA   Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P.,
RA   Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G.,
RA   Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A.,
RA   Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.;
RT   "Genetically-defined novel oral squamous cell carcinoma cell lines for
RT   the development of molecular therapies.";
RL   Oncotarget 7:27802-27818(2016).
//
RX   PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259;
RA   Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H.,
RA   Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C.,
RA   McDermott U., Garnett M.J., Cheong S.-C.;
RT   "Genome-wide CRISPR screens of oral squamous cell carcinoma reveal
RT   fitness genes in the Hippo pathway.";
RL   eLife 9:e57761.1-e57761.34(2020).
//