ID   ORL-188
AC   CVCL_VJ42
SY   ORL-188T; 188T
DR   BioGRID_ORCS_Cell_line; 1276
DR   Cell_Model_Passport; SIDM02000
DR   Cosmic; 2531655
DR   Cosmic; 2559742
DR   Wikidata; Q98128362
RX   PubMed=24224046;
RX   PubMed=27050151;
RX   PubMed=32990596;
CC   Population: Malaysian.
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu69Ter (c.205G>T) (p.Gly83Val, c.248G>T); ClinVar=VCV000376308; Zygosity=Heterozygous (PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Glu204_Tyr205del (c.609_614del); Zygosity=Unspecified (PubMed=27050151).
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Oral cavity, tongue; UBERON=UBERON_0001723.
ST   Source(s): PubMed=27050151
ST   Amelogenin: X,Y
ST   CSF1PO: 9,12
ST   D13S317: 8,11
ST   D16S539: 10
ST   D18S51: 17,19
ST   D19S433: 14,14.2
ST   D21S11: 31
ST   D2S1338: 19
ST   D3S1358: 16
ST   D5S818: 10,13
ST   D7S820: 10,11
ST   D8S1179: 13,16
ST   FGA: 24.2,27
ST   TH01: 7,8
ST   TPOX: 9
ST   vWA: 16
DI   NCIt; C4648; Tongue squamous cell carcinoma
DI   ORDO; Orphanet_457252; Squamous cell carcinoma of the oral tongue
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   56Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 10-04-25; Version: 12
//
RX   PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115;
RA   Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A.,
RA   Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.;
RT   "Common oncogenic mutations are infrequent in oral squamous cell
RT   carcinoma of Asian origin.";
RL   PLoS ONE 8:e80229.1-e80229.12(2013).
//
RX   PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689;
RA   Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P.,
RA   Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G.,
RA   Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A.,
RA   Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.;
RT   "Genetically-defined novel oral squamous cell carcinoma cell lines for
RT   the development of molecular therapies.";
RL   Oncotarget 7:27802-27818(2016).
//
RX   PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259;
RA   Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H.,
RA   Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C.,
RA   McDermott U., Garnett M.J., Cheong S.-C.;
RT   "Genome-wide CRISPR screens of oral squamous cell carcinoma reveal
RT   fitness genes in the Hippo pathway.";
RL   eLife 9:e57761.1-e57761.34(2020).
//