ID   ORL-153
AC   CVCL_VJ38
SY   ORL-153T; 153T
DR   BioGRID_ORCS_Cell_line; 1274
DR   cancercelllines; CVCL_VJ38
DR   Cell_Model_Passport; SIDM02004
DR   Cosmic; 2531651
DR   Cosmic; 2559738
DR   Wikidata; Q98128357
RX   PubMed=24224046;
RX   PubMed=27050151;
RX   PubMed=32990596;
CC   Population: Indian.
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Arg80Ter (c.238C>T) (p.Pro94Leu, c.281C>T); ClinVar=VCV000009409; Zygosity=Homozygous (PubMed=27050151).
CC   Sequence variation: Mutation; HGNC; HGNC:3595; FAT1; Simple; p.Tyr997Ter (c.2991T>G); Zygosity=Unspecified (PubMed=27050151).
CC   Omics: Phenotyping; CRISPR screening.
CC   Omics: Transcriptomics; RNAseq.
CC   Derived from site: In situ; Oral cavity, gingiva; UBERON=UBERON_0001828.
ST   Source(s): PubMed=27050151
ST   Amelogenin: X,Y
ST   CSF1PO: 10
ST   D13S317: 10,14
ST   D16S539: 12
ST   D18S51: 13,14
ST   D19S433: 14,16
ST   D21S11: 28,31
ST   D2S1338: 19,23
ST   D3S1358: 16,17
ST   D5S818: 11,12
ST   D7S820: 7,12
ST   D8S1179: 10,17
ST   FGA: 21
ST   TH01: 9,9.3
ST   TPOX: 11
ST   vWA: 17,18
DI   NCIt; C129857; Gingival squamous cell carcinoma
DI   ORDO; Orphanet_502363; Squamous cell carcinoma of the oral cavity
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   36Y
CA   Cancer cell line
DT   Created: 07-09-18; Last updated: 10-04-25; Version: 12
//
RX   PubMed=24224046; DOI=10.1371/journal.pone.0080229; PMCID=PMC3817115;
RA   Zanaruddin S.N.S., Yee P.-S., Hor S.Y., Kong Y.H., Ghani W.M.N.W.A.,
RA   Mustafa W.M.W., Zain R.B., Prime S.S., Rahman Z.A.A., Cheong S.-C.;
RT   "Common oncogenic mutations are infrequent in oral squamous cell
RT   carcinoma of Asian origin.";
RL   PLoS ONE 8:e80229.1-e80229.12(2013).
//
RX   PubMed=27050151; DOI=10.18632/oncotarget.8533; PMCID=PMC5053689;
RA   Fadlullah M.Z.H., Chiang I.K.-N., Dionne K.R., Yee P.-S., Gan C.P.,
RA   Sam K.K., Tiong K.H., Ng A.K.W., Martin D., Lim K.P., Kallarakkal T.G.,
RA   Mustafa W.M.W., Lau S.H., Abraham M.T., Zain R.B., Rahman Z.A.A.,
RA   Molinolo A.A., Patel V., Gutkind J.S., Tan A.-C., Cheong S.-C.;
RT   "Genetically-defined novel oral squamous cell carcinoma cell lines for
RT   the development of molecular therapies.";
RL   Oncotarget 7:27802-27818(2016).
//
RX   PubMed=32990596; DOI=10.7554/eLife.57761; PMCID=PMC7591259;
RA   Chai A.W.-Y., Yee P.-S., Price S., Yee S.-M., Lee H.-M., Tiong V.K.H.,
RA   Goncalves E., Behan F.M., Bateson J., Gilbert J.G.R., Tan A.-C.,
RA   McDermott U., Garnett M.J., Cheong S.-C.;
RT   "Genome-wide CRISPR screens of oral squamous cell carcinoma reveal
RT   fitness genes in the Hippo pathway.";
RL   eLife 9:e57761.1-e57761.34(2020).
//