ID   U-M
AC   CVCL_VG84
SY   UM
DR   cancercelllines; CVCL_VG84
DR   Wikidata; Q54973622
RX   DOI=10.1007/978-94-011-3550-4_20;
RX   PubMed=2243057;
CC   Population: Caucasian.
CC   Characteristics: Obtained by treatment of parent cell line with TPA in eRDF medium (DOI=10.1007/978-94-011-3550-4_20).
CC   Sequence variation: Gene fusion; HGNC; HGNC:16063; MLLT10 + HGNC; HGNC:15514; PICALM; Name(s)=PICALM-MLLT10, CALM-AF10 (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; p.Gly129fs*51 (c.387_388insCGCC); Zygosity=Hemizygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9644; PTPN11; Simple; p.Gly60Arg (c.178G>C); ClinVar=VCV000372590; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; c.559+1G>A (p.Val173Trpfs*59); ClinVar=VCV000428908; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:12796; WT1; Simple; p.Arg301Ter (c.901C>T) (p.Arg352Ter, c.1054C>T) (p.Arg374Ter, c.1120C>T); ClinVar=VCV000449416; Zygosity=Heterozygous (from parent cell line).
CC   Derived from site: In situ; Pleural effusion; UBERON=UBERON_0000175.
DI   NCIt; C8263; Adult acute monocytic leukemia
DI   ORDO; Orphanet_514; Acute monoblastic/monocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0007 ! U-937
SX   Male
AG   37Y
CA   Cancer cell line
DT   Created: 14-05-18; Last updated: 19-12-24; Version: 13
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RX   DOI=10.1007/978-94-011-3550-4_20;
RA   Shinohara, Kazuki
RA   Kong, Zwe-Ling
RA   Murakami, Hiroki
RT   "Characterization of a human derived macrophage-like cell line, U-M.";
RL   (In book chapter) Animal cell culture and production of biologicals; Sasaki, Ryuzo & Ikura, Koji (eds.); pp.181-186; Springer; Dordrecht; Netherlands (1991).
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RX   PubMed=2243057; DOI=10.1007/BF02624468;
RA   Kong, Zwe-Ling
RA   Miwa, Misao
RA   Murakami, Hiroki
RA   Shinohara, Kazuki
RT   "Establishment of a macrophagelike cell line derived from U-937, human
RT   histiocytic lymphoma, grown serum-free.";
RL   In Vitro Cell. Dev. Biol. 26:949-954(1990).
//