ID   HMGEC
AC   CVCL_VF64
SY   IHMGEC; Human Meibomian Gland Epithelial Cells
DR   ATCC; CRL-3472
DR   Wikidata; Q54889933
RX   PubMed=20335607;
RX   PubMed=26042605;
RX   PubMed=28363775;
RX   PubMed=29625457;
RX   PubMed=29787296;
CC   Doubling time: 27.39 hours (PubMed=20335607); ~3-7 days (ATCC=CRL-3472).
CC   Genetic integration: Method=Transduction; Gene=HGNC; HGNC:11730; TERT.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P00552; Klebsiella pneumoniae transposon Tn5 neo.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P03070; Simian virus 40 (SV40) large T antigen.
CC   Genetic integration: Method=Transduction; Gene=UniProtKB; P13249; Streptomyces alboniger pac (PuroR).
CC   Transformant: NCBI_TaxID; 1891767; Simian virus 40 (SV40).
CC   Derived from site: In situ; Meibomian gland; UBERON=UBERON_0001818.
CC   Cell type: Epithelial cell; CL=CL_0000066.
ST   Source(s): PubMed=29787296
ST   Amelogenin: X,Y
ST   CSF1PO: 10,12
ST   D13S317: 9,14
ST   D16S539: 8,11
ST   D18S51: 12,16
ST   D21S11: 29,30.2
ST   D3S1358: 15,17
ST   D5S818: 10,13
ST   D7S820: 8,11
ST   D8S1179: 13,15
ST   FGA: 23,24
ST   Penta D: 8,12
ST   Penta E: 5,14
ST   TH01: 6,9.3
ST   TPOX: 8,9
ST   vWA: 16,17
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   58Y
CA   Transformed cell line
DT   Created: 14-05-18; Last updated: 14-08-25; Version: 13
//
RX   PubMed=20335607; DOI=10.1167/iovs.09-5108; PMCID=PMC2910637;
RA   Liu, Shao-Hui
RA   Hatton, Mark P.
RA   Khandelwal, Payal
RA   Sullivan, David A.
RT   "Culture, immortalization, and characterization of human meibomian
RT   gland epithelial cells.";
RL   Invest. Ophthalmol. Vis. Sci. 51:3993-4005(2010).
//
RX   PubMed=26042605; DOI=10.1371/journal.pone.0128096; PMCID=PMC4456149;
RA   Hampel, Ulrike
RA   Schroder, Antje
RA   Mitchell, Todd
RA   Brown, Simon
RA   Snikeris, Peta
RA   Garreis, Fabian
RA   Kunnen, Carolina
RA   Willcox, Mark
RA   Paulsen, Friedrich
RT   "Serum-induced keratinization processes in an immortalized human
RT   meibomian gland epithelial cell line.";
RL   PLoS ONE 10:e0128096.1-e0128096.18(2015).
//
RX   PubMed=28363775; DOI=10.1016/j.exer.2017.03.011;
RA   Hampel, Ulrike
RA   Garreis, Fabian
RT   "The human meibomian gland epithelial cell line as a model to study
RT   meibomian gland dysfunction.";
RL   Exp. Eye Res. 163:46-52(2017).
//
RX   PubMed=29625457; DOI=10.1167/iovs.17-23266;
RA   Asano, Nagayoshi
RA   Hampel, Ulrike
RA   Garreis, Fabian
RA   Schroder, Antje
RA   Schicht, Martin
RA   Hammer, Christian M.
RA   Paulsen, Friedrich
RT   "Differentiation patterns of immortalized human meibomian gland
RT   epithelial cells in three-dimensional culture.";
RL   Invest. Ophthalmol. Vis. Sci. 59:1343-1353(2018).
//
RX   PubMed=29787296; DOI=10.1080/02713683.2018.1480043; PMCID=PMC6590053;
RA   McDermott, Alison M.
RA   Baidouri, Hasna
RA   Woodward, Ashley M.
RA   Kam, Wendy R.
RA   Liu, Yang
RA   Chen, Xiao-Min
RA   Ziemanski, Jillian F.
RA   Vistisen, Kerry
RA   Hazlett, Linda D.
RA   Nichols, Kelly K.
RA   Argueso, Pablo
RA   Sullivan, David A.
RT   "Short tandem repeat (STR) profiles of commonly used human ocular
RT   surface cell lines.";
RL   Curr. Eye Res. 43:1097-1101(2018).
//