ID   HCC827 GR5
AC   CVCL_V622
SY   HCC827-GR5; HCC-827-GR5; HCC827GR5
DR   BioSample; SAMN10988418
DR   cancercelllines; CVCL_V622
DR   Cell_Model_Passport; SIDM01636
DR   DepMap; ACH-000029
DR   GEO; GSM466322
DR   PharmacoDB; HCC827GR5_462_2019
DR   Progenetix; CVCL_V622
DR   Wikidata; Q54881790
RX   PubMed=17463250;
RX   PubMed=20716641;
RX   PubMed=25984343;
RX   PubMed=31068700;
CC   Part of: Cancer Dependency Map project (DepMap) (includes Cancer Cell Line Encyclopedia - CCLE).
CC   Population: Caucasian.
CC   Doubling time: 48 hours (PubMed=25984343).
CC   Selected for resistance to: ChEBI; CHEBI:49668; Gefitinib (ZD1839; Iressa).
CC   Sequence variation: Mutation; HGNC; 3236; EGFR; Simple; p.Glu746_Ala750del (c.2236_2250del15); ClinVar=VCV000177620; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Val218del (c.646_648GTG[2]) (c.652_654delGTG); ClinVar=VCV000634761; Zygosity=Homozygous (from parent cell line).
CC   Omics: Deep exome analysis.
CC   Omics: shRNA library screening.
CC   Derived from site: In situ; Lung; UBERON=UBERON_0002048.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_2063 ! HCC827
SX   Female
AG   39Y
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 05-10-23; Version: 19
//
RX   PubMed=17463250; DOI=10.1126/science.1141478;
RA   Engelman J.A., Zejnullahu K., Mitsudomi T., Song Y., Hyland C.,
RA   Park J.O., Lindeman N.I., Gale C.-M., Zhao X.-J., Christensen J.G.,
RA   Kosaka T., Holmes A.J., Rogers A.M., Cappuzzo F., Mok T., Lee C.,
RA   Johnson B.E., Cantley L.C., Janne P.A.;
RT   "MET amplification leads to gefitinib resistance in lung cancer by
RT   activating ERBB3 signaling.";
RL   Science 316:1039-1043(2007).
//
RX   PubMed=20716641; DOI=10.1158/1535-7163.MCT-10-0481;
RA   Okamoto W., Okamoto I., Tanaka K., Hatashita E., Yamada Y., Kuwata K.,
RA   Yamaguchi H., Arao T., Nishio K., Fukuoka M., Janne P.A.,
RA   Nakagawa K.;
RT   "TAK-701, a humanized monoclonal antibody to hepatocyte growth factor,
RT   reverses gefitinib resistance induced by tumor-derived HGF in
RT   non-small cell lung cancer with an EGFR mutation.";
RL   Mol. Cancer Ther. 9:2785-2792(2010).
//
RX   PubMed=25984343; DOI=10.1038/sdata.2014.35;
RA   Cowley G.S., Weir B.A., Vazquez F., Tamayo P., Scott J.A., Rusin S.,
RA   East-Seletsky A., Ali L.D., Gerath W.F.J., Pantel S.E., Lizotte P.H.,
RA   Jiang G.-Z., Hsiao J., Tsherniak A., Dwinell E., Aoyama S., Okamoto M.,
RA   Harrington W., Gelfand E.T., Green T.M., Tomko M.J., Gopal S.,
RA   Wong T.C., Li H.-B., Howell S., Stransky N., Liefeld T., Jang D.,
RA   Bistline J., Meyers B.H., Armstrong S.A., Anderson K.C.,
RA   Stegmaier K., Reich M., Pellman D., Boehm J.S., Mesirov J.P.,
RA   Golub T.R., Root D.E., Hahn W.C.;
RT   "Parallel genome-scale loss of function screens in 216 cancer cell
RT   lines for the identification of context-specific genetic
RT   dependencies.";
RL   Sci. Data 1:140035-140035(2014).
//
RX   PubMed=31068700; DOI=10.1038/s41586-019-1186-3;
RA   Ghandi M., Huang F.W., Jane-Valbuena J., Kryukov G.V., Lo C.C.,
RA   McDonald E.R. III, Barretina J.G., Gelfand E.T., Bielski C.M., Li H.-X.,
RA   Hu K., Andreev-Drakhlin A.Y., Kim J., Hess J.M., Haas B.J., Aguet F.,
RA   Weir B.A., Rothberg M.V., Paolella B.R., Lawrence M.S., Akbani R.,
RA   Lu Y.-L., Tiv H.L., Gokhale P.C., de Weck A., Mansour A.A., Oh C.,
RA   Shih J., Hadi K., Rosen Y., Bistline J., Venkatesan K., Reddy A.,
RA   Sonkin D., Liu M., Lehar J., Korn J.M., Porter D.A., Jones M.D.,
RA   Golji J., Caponigro G., Taylor J.E., Dunning C.M., Creech A.L.,
RA   Warren A.C., McFarland J.M., Zamanighomi M., Kauffmann A.,
RA   Stransky N., Imielinski M., Maruvka Y.E., Cherniack A.D.,
RA   Tsherniak A., Vazquez F., Jaffe J.D., Lane A.A., Weinstock D.M.,
RA   Johannessen C.M., Morrissey M.P., Stegmeier F., Schlegel R.,
RA   Hahn W.C., Getz G., Mills G.B., Boehm J.S., Golub T.R., Garraway L.A.,
RA   Sellers W.R.;
RT   "Next-generation characterization of the Cancer Cell Line
RT   Encyclopedia.";
RL   Nature 569:503-508(2019).
//