ID   PICM-19
AC   CVCL_V146
SY   ARS-PICM-19; Pig Inner Cell Mass-19
DR   Wikidata; Q54947385
RX   PubMed=7534591;
RX   PubMed=8354665;
RX   PubMed=8635514;
RX   PubMed=12097833;
RX   PubMed=20333478;
RX   PubMed=20669140;
RX   PubMed=23148238;
CC   Group: Space-flown cell line (cellonaut).
CC   Characteristics: Requires feeder cells.
CC   Anecdotal: Have been flown in space on shuttle flight STS-126 to study growth and differentiation in microgravity (PubMed=20333478).
CC   Derived from site: In situ; Fetal liver; UBERON=UBERON_0002107.
CC   Cell type: Hepatocyte; CL=CL_0000182.
OX   NCBI_TaxID=9823; ! Sus scrofa (Pig)
SX   Sex unspecified
AG   8FD
CA   Spontaneously immortalized cell line
DT   Created: 16-04-14; Last updated: 29-06-23; Version: 10
RX   PubMed=7534591; DOI=10.1007/BF02639394;
RA   Talbot N.C., Rexroad C.E. Jr., Powell A.M., Pursel V.G., Caperna T.J.,
RA   Ogg S.L., Nel N.D.;
RT   "A continuous culture of pluripotent fetal hepatocytes derived from
RT   the 8-day epiblast of the pig.";
RL   In Vitro Cell. Dev. Biol. Anim. 30:843-850(1994).
RX   PubMed=8354665; DOI=10.1007/BF02634148;
RA   Talbot N.C., Rexroad C.E. Jr., Pursel V.G., Powell A.M., Nel N.D.;
RT   "Culturing the epiblast cells of the pig blastocyst.";
RL   In Vitro Cell. Dev. Biol. Anim. 29:543-554(1993).
RX   PubMed=8635514; DOI=10.1006/excr.1996.0153;
RA   Talbot N.C., Caperna T.J., Lebow L.T., Moscioni A.D., Pursel V.G.,
RA   Rexroad C.E. Jr.;
RT   "Ultrastructure, enzymatic, and transport properties of the PICM-19
RT   bipotent liver cell line.";
RL   Exp. Cell Res. 225:22-34(1996).
RX   PubMed=12097833; DOI=10.1159/000063704;
RA   Talbot N.C., Caperna T.J., Wells K.D.;
RT   "The PICM-19 cell line as an in vitro model of liver bile ductules:
RT   effects of cAMP inducers, biopeptides and pH.";
RL   Cells Tissues Organs 171:99-116(2002).
RX   PubMed=20333478; DOI=10.1007/s11626-010-9302-6;
RA   Talbot N.C., Caperna T.J., Blomberg L.A., Graninger P.G.,
RA   Stodieck L.S.;
RT   "The effects of space flight and microgravity on the growth and
RT   differentiation of PICM-19 pig liver stem cells.";
RL   In Vitro Cell. Dev. Biol. Anim. 46:502-515(2010).
RX   PubMed=20669140; DOI=10.1177/039139881003300603;
RA   Talbot N.C., Caperna T.J., Willard R.R., Meekin J.H., Garrett W.M.;
RT   "Characterization of two subpopulations of the PICM-19 porcine liver
RT   stem cell line for use in cell-based extracorporeal liver assistance
RT   devices.";
RL   Int. J. Artif. Organs 33:348-361(2010).
RX   PubMed=23148238; DOI=10.2527/jas.2012-5748;
RA   Talbot N.C., Caperna T.J., Garrett W.M.;
RT   "Growth and development symposium: development, characterization, and
RT   use of a porcine epiblast-derived liver stem cell line: ARS-PICM-19.";
RL   J. Anim. Sci. 91:66-77(2013).