ID   AHH-1 TK+/-
AC   CVCL_UU61
SY   AHH-1 tk+/-; AHH-1 tk +/-
DR   IARC_TP53; 7283
DR   Wikidata; Q93323819
RX   PubMed=2307151;
RX   PubMed=7739402;
RX   PubMed=7923587;
RX   PubMed=8625943;
RX   PubMed=8841477;
CC   Population: Caucasian.
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg282Trp (c.844C>T); ClinVar=VCV000012364; Zygosity=Unspecified (PubMed=8841477).
CC   Transformant: NCBI_TaxID; 10376; Epstein-Barr virus (EBV).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: B-cell; CL=CL_0000236.
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_3640 ! AHH-1
SX   Male
AG   33Y
CA   Transformed cell line
DT   Created: 25-02-19; Last updated: 10-04-25; Version: 8
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RX   PubMed=2307151; DOI=10.1002/em.2850150203;
RA   Crespi C.L., Seixas G.M., Turner T., Penman B.W.;
RT   "Sodium fluoride is a less efficient human cell mutagen at low
RT   concentrations.";
RL   Environ. Mol. Mutagen. 15:71-77(1990).
//
RX   PubMed=7739402; DOI=10.1093/mutage/10.1.53;
RA   Dobo K.L., Giver C.R., Eastmond D.A., Rumbos H.S., Grosovsky A.J.;
RT   "Extensive loss of heterozygosity accounts for differential mutation
RT   rate on chromosome 17q in human lymphoblasts.";
RL   Mutagenesis 10:53-58(1995).
//
RX   PubMed=7923587; DOI=10.1093/carcin/15.9.1931;
RA   Penman B.W., Chen L.-P., Gelboin H.V., Gonzalez F.J., Crespi C.L.;
RT   "Development of a human lymphoblastoid cell line constitutively
RT   expressing human CYP1A1 cDNA: substrate specificity with model
RT   substrates and promutagens.";
RL   Carcinogenesis 15:1931-1937(1994).
//
RX   PubMed=8625943; DOI=10.1002/(SICI)1098-2280(1996)27:1<10::AID-EM2>3.0.CO;2-I;
RA   Morris S.M., McGarrity L.J., Domon O.E., Chen J.J., Casciano D.A.;
RT   "Cell cycle traverse in AHH-1 tk +/- human lymphoblastoid cells
RT   exposed to the chromosomal mutagen, m-amsa.";
RL   Environ. Mol. Mutagen. 27:10-18(1996).
//
RX   PubMed=8841477; DOI=10.1016/0027-5107(96)00133-9;
RA   Morris S.M., Manjanatha M.G., Shelton S.D., Domon O.E.,
RA   McGarrity L.J., Casciano D.A.;
RT   "A mutation in the p53 tumor suppressor gene of AHH-1 tk+/- human
RT   lymphoblastoid cells.";
RL   Mutat. Res. 356:129-134(1996).
//