ID   HPB/VP-16
AC   CVCL_UJ10
DR   Wikidata; Q94216712
RX   PubMed=1370437;
RX   PubMed=8099376;
CC   Problematic cell line: Contaminated. Parent cell line (HPB-MLT) has been shown to be a HPB-ALL derivative.
CC   Population: Japanese.
CC   Selected for resistance to: ChEBI; CHEBI:4911; Etoposide (VP-16).
CC   Sequence variation: Gene fusion; HGNC; 1539; CBFB + HGNC; 29824; MYL11; Name(s)=CBFB-MYL11, CBFB-MYLPF (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Leu1574Pro (c.4721T>C); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 7881; NOTCH1; Simple; p.Asp2442fs*39 (c.7326_7326insGGGCCGTGGACG); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Cys124Ter (c.372C>A); ClinVar=VCV000458537; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Peripheral blood; UBERON=UBERON_0000178.
CC   Cell type: T-cell; CL=CL_0000084.
DI   NCIt; C7953; Childhood T acute lymphoblastic leukemia
DI   ORDO; Orphanet_99861; Precursor T-cell acute lymphoblastic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_7959 ! HPB-MLT
SX   Male
AG   14Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 29-06-23; Version: 11
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RX   PubMed=1370437; DOI=10.1002/ijc.2910500223;
RA   Treichel R.S., Olken S.;
RT   "The relationship between multi-drug resistance and resistance to
RT   natural-killer-cell and lymphokine-activated killer-cell lysis in
RT   human leukemic cell lines.";
RL   Int. J. Cancer 50:305-310(1992).
//
RX   PubMed=8099376; DOI=10.1016/0145-2126(93)90124-4;
RA   Treichel R.S.;
RT   "Autologous bone marrow transplantation for leukemia: monoclonal
RT   antibody-mediated purging of multidrug-resistant leukemia.";
RL   Leuk. Res. 17:491-499(1993).
//