ID   SKOV3-CisR
AC   CVCL_UI88
DR   cancercelllines; CVCL_UI88
DR   Wikidata; Q98132684
RX   PubMed=21372221;
CC   Population: Caucasian.
CC   Selected for resistance to: ChEBI; CHEBI:27899; Cisplatin (CDDP).
CC   Sequence variation: Mutation; HGNC; 583; APC; Simple; p.Thr1556Leufs*9 (c.4666delA); ClinVar=VCV000156477; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 16712; FBXW7; Simple; p.Arg505Leu (c.1514G>T); ClinVar=VCV000376424; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 8975; PIK3CA; Simple; p.His1047Arg (c.3140A>G); ClinVar=VCV000013652; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Ser90Profs*33 (c.267delC); ClinVar=VCV000156515; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: Metastatic; Ascites; UBERON=UBERON_0007795.
DI   NCIt; C7978; Ovarian serous cystadenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0532 ! SK-OV-3
SX   Female
AG   64Y
CA   Cancer cell line
DT   Created: 25-02-19; Last updated: 05-10-23; Version: 8
//
RX   PubMed=21372221; DOI=10.1158/1078-0432.CCR-10-2289;
RA   Santiskulvong C., Konecny G.E., Fekete M., Chen K.-Y.M., Karam A.,
RA   Mulholland D., Eng C., Wu H., Song M., Dorigo O.;
RT   "Dual targeting of phosphoinositide 3-kinase and mammalian target of
RT   rapamycin using NVP-BEZ235 as a novel therapeutic approach in human
RT   ovarian carcinoma.";
RL   Clin. Cancer Res. 17:2373-2384(2011).
//