ID   U-87MG ATCC IDH1 p.R132H
AC   CVCL_UE09
SY   IDH1 mutant-U-87 Isogenic Cell Line
DR   ATCC; HTB-14IG
DR   cancercelllines; CVCL_UE09
DR   Wikidata; Q98133708
CC   Problematic cell line: Misidentified. Parent cell line (U-87MG ATCC) is not the original glioblastoma cell line established in 1968 at the University of Uppsala.
CC   Population: Caucasian.
CC   Doubling time: ~25.6 hours (ATCC=HTB-14IG).
CC   Sequence variation: Mutation; HGNC; HGNC:5382; IDH1; Simple_edited; p.Arg132His (c.395G>A); ClinVar=VCV000156444; Zygosity=Heterozygous; Note=By CRISPR/Cas9 (ATCC=HTB-14IG).
CC   Sequence variation: Mutation; HGNC; HGNC:7765; NF1; Simple; p.Phe1247Ilefs*18 (c.3739_3742delTTTG) (3737_3740delTGTT); ClinVar=VCV000420078; Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:9588; PTEN; Simple; c.209+1G>T; ClinVar=VCV000229705; Zygosity=Homozygous; Note=Splice donor mutation (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11730; TERT; Simple; c.1-124C>T (c.228C>T) (C228T); Zygosity=Unspecified; Note=In promoter (from parent cell line).
ST   Source(s): ATCC=HTB-14IG
ST   Amelogenin: X
ST   CSF1PO: 10,11
ST   D13S317: 8,11
ST   D16S539: 12
ST   D5S818: 11,12
ST   D7S820: 8,9
ST   TH01: 9.3
ST   TPOX: 8
ST   vWA: 15,17
DI   NCIt; C3058; Glioblastoma
DI   ORDO; Orphanet_360; Glioblastoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_0022 ! U-87MG ATCC
SX   Male
AG   Age unspecified
CA   Cancer cell line
DT   Created: 13-11-18; Last updated: 19-12-24; Version: 11
CH   CVCL_UR35 ! U-87MG ATCC IDH1 p.R132H-Luc2
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