ID   Detroit 98/AH
AC   CVCL_U961
SY   Det98/AH; D98/AH
DR   BioSample; SAMN03151677
DR   Wikidata; Q54831008
RX   CelloPub=CLPUB00640;
RX   PubMed=13980043;
RX   PubMed=14278461;
RX   PubMed=20143388;
WW   Info; ICLAC; -; https://iclac.org/wp-content/uploads/Cross-Contaminations_v13_distribution.xlsx
CC   Problematic cell line: Contaminated. Ancestral cell line (Detroit 98) has been shown to be a HeLa derivative (PubMed=20143388).
CC   Registration: International Cell Line Authentication Committee, Register of Misidentified Cell Lines; ICLAC-00115.
CC   Population: African American.
CC   Selected for resistance to: ChEBI; CHEBI_63486; 8-azaguanine.
CC   Selected for resistance to: ChEBI; CHEBI_136532; 8-azahypoxanthine.
CC   Transformant: NCBI_TaxID; 333761; Human papillomavirus type 18 (HPV18).
CC   Derived from site: In situ; Uterus, cervix; UBERON=UBERON_0000002.
DI   NCIt; C27677; Human papillomavirus-related endocervical adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8189 ! Detroit 98/AG
SX   Female
AG   30Y6M
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 10-04-25; Version: 19
CH   CVCL_8191 ! Detroit 98/AH-R
//
RX   PubMed=13980043; DOI=10.1073/pnas.48.12.2026; PMCID=PMC221117;
RA   Szybalska, Elizabeth Hunter
RA   Szybalski, Waclaw
RT   "Genetics of human cell line. IV. DNA-mediated heritable
RT   transformation of a biochemical trait.";
RL   Proc. Natl. Acad. Sci. U.S.A. 48:2026-2034(1962).
//
RX   CelloPub=CLPUB00640;
RA   Szybalski, Waclaw
RA   Szybalska, Elizabeth Hunter
RA   Ragni, Giorgio
RT   "Genetic studies with human cell lines.";
RL   Natl. Cancer Inst. Monogr. 7:75-89(1962).
//
RX   PubMed=20143388; DOI=10.1002/ijc.25242;
RA   Capes-Davis, Amanda
RA   Theodosopoulos, George
RA   Atkin, Isobel
RA   Drexler, Hans Gunther
RA   Kohara, Arihiro
RA   MacLeod, Roderick A.F.
RA   Masters, John R.W.
RA   Nakamura, Yukio
RA   Reid, Yvonne A.
RA   Reddel, Roger Robert
RA   Freshney, Robert Ian
RT   "Check your cultures! A list of cross-contaminated or misidentified
RT   cell lines.";
RL   Int. J. Cancer 127:1-8(2010).
//
RX   PubMed=14278461; DOI=10.1101/sqb.1964.029.01.019;
RA   Szybalski, Waclaw
RT   "Chemical reactivity of chromosomal DNA as related to mutagenicity:
RT   studies with human cell lines.";
RL   Cold Spring Harb. Symp. Quant. Biol. 29:151-159(1964).
//