ID   BL
AC   CVCL_U802
SY   BLmel; BL mel
DR   cancercelllines; CVCL_U802
DR   Cosmic; 888987
DR   Cosmic; 897737
DR   Cosmic; 928724
DR   GEO; GSM170823
DR   Wikidata; Q54797091
RX   PubMed=1697409;
RX   PubMed=9331097;
RX   PubMed=9354451;
RX   PubMed=15048078;
RX   PubMed=15688405;
RX   PubMed=17516929;
RX   PubMed=19383913;
RX   PubMed=22383533;
RX   PubMed=23039341;
CC   Sequence variation: Mutation; HGNC; HGNC:1097; BRAF; Simple; p.Val600Glu (c.1799T>A); ClinVar=VCV000013961; Zygosity=Unspecified (PubMed=15048078; PubMed=22383533).
CC   Sequence variation: Mutation; HGNC; HGNC:1787; CDKN2A; Simple; p.Glu88Lys (c.262G>A); ClinVar=VCV000821566; Zygosity=Unspecified (PubMed=9354451).
CC   Omics: Transcriptomics; Microarray.
DI   NCIt; C3224; Melanoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Sex unspecified
AG   Age unspecified
CA   Cancer cell line
DT   Created: 16-04-14; Last updated: 14-08-25; Version: 17
//
RX   PubMed=22383533; DOI=10.1158/1535-7163.MCT-11-0676;
RA   Dutton-Regester, Ken
RA   Irwin, Darryl
RA   Hunt, Priscilla
RA   Aoude, Lauren G.
RA   Tembe, Varsha
RA   Pupo, Gulietta M.
RA   Lanagan, Cathy
RA   Carter, Candace D.
RA   O'Connor, Linda
RA   O'Rourke, Michael
RA   Scolyer, Richard Anthony
RA   Mann, Graham J.
RA   Schmidt, Christopher W.
RA   Herington, Adrian
RA   Hayward, Nicholas K.
RT   "A high-throughput panel for identifying clinically relevant mutation
RT   profiles in melanoma.";
RL   Mol. Cancer Ther. 11:888-897(2012).
//
RX   PubMed=15048078; DOI=10.1038/sj.onc.1207563;
RA   Pavey, Sandra
RA   Johansson, Peter
RA   Packer, Leisl
RA   Taylor, Jennifer
RA   Stark, Mitchell S.
RA   Pollock, Pamela M.
RA   Walker, Graeme J.
RA   Boyle, Glen M.
RA   Harper, Ursula
RA   Cozzi, Sarah-Jane
RA   Hansen, Katherine
RA   Yudt, Laura
RA   Schmidt, Chris
RA   Hersey, Peter
RA   Ellem, Kay Adrian Oswald
RA   O'Rourke, Michael G.E.
RA   Parsons, Peter G.
RA   Meltzer, Paul S.
RA   Ringner, Markus
RA   Hayward, Nicholas K.
RT   "Microarray expression profiling in melanoma reveals a BRAF mutation
RT   signature.";
RL   Oncogene 23:4060-4067(2004).
//
RX   PubMed=15688405; DOI=10.1002/ijc.20873;
RA   Eskandarpour, Malihe
RA   Kiaii, Shahryar
RA   Zhu, Chao-Yong
RA   Castro, Juan
RA   Sakko, Andrew J.
RA   Hansson, Johan
RT   "Suppression of oncogenic NRAS by RNA interference induces apoptosis
RT   of human melanoma cells.";
RL   Int. J. Cancer 115:65-73(2005).
//
RX   PubMed=9354451;
RA   Castellano, Marina
RA   Pollock, Pamela M.
RA   Walters, Marilyn K.
RA   Sparrow, Louise E.
RA   Down, Louise M.
RA   Gabrielli, Brian G.
RA   Parsons, Peter G.
RA   Hayward, Nicholas K.
RT   "CDKN2A/p16 is inactivated in most melanoma cell lines.";
RL   Cancer Res. 57:4868-4875(1997).
//
RX   PubMed=19383913; DOI=10.1158/0008-5472.CAN-08-3746;
RA   Cedervall, Jessica
RA   Jamil, Seema
RA   Prasmickaite, Lina
RA   Cheng, Yen-Fu
RA   Eskandarpour, Malihe
RA   Hansson, Johan
RA   Maelandsmo, Gunhild Mari
RA   Ringborg, Ulrik
RA   Gulyas, Miklos
RA   Zhen, He-Suo
RA   Kanter, Lena
RA   Ahrlund-Richter, Lars
RT   "Species-specific in vivo engraftment of the human BL melanoma cell
RT   line results in an invasive dedifferentiated phenotype not present in
RT   xenografts.";
RL   Cancer Res. 69:3746-3754(2009).
//
RX   PubMed=9331097;
RA   Salazar-Onfray, Flavio
RA   Nakazawa, Tsutomu
RA   Chhajlani, Vijay
RA   Petersson, Max
RA   Karre, Klas
RA   Masucci, Giuseppe
RA   Celis, Esteban
RA   Sette, Alessandro
RA   Southwood, Scott
RA   Appella, Ettore
RA   Kiessling, Rolf
RT   "Synthetic peptides derived from the melanocyte-stimulating hormone
RT   receptor MC1R can stimulate HLA-A2-restricted cytotoxic T lymphocytes
RT   that recognize naturally processed peptides on human melanoma
RT   cells.";
RL   Cancer Res. 57:4348-4355(1997).
//
RX   PubMed=17516929; DOI=10.1111/j.1600-0749.2007.00375.x;
RA   Johansson, Peter
RA   Pavey, Sandra
RA   Hayward, Nicholas K.
RT   "Confirmation of a BRAF mutation-associated gene expression signature
RT   in melanoma.";
RL   Pigment Cell Res. 20:216-221(2007).
//
RX   PubMed=1697409;
RA   Chenevix-Trench, Georgia
RA   Martin, Nicholas Gordon
RA   Ellem, Kay Adrian Oswald
RT   "Gene expression in melanoma cell lines and cultured melanocytes:
RT   correlation between levels of c-src-1, c-myc and p53.";
RL   Oncogene 5:1187-1193(1990).
//
RX   PubMed=23039341; DOI=10.1186/1476-4598-11-75; PMCID=PMC3554420;
RA   Byron, Sara A.
RA   Loch, David C.
RA   Wellens, Candice L.
RA   Wortmann, Andreas
RA   Wu, Jia-Yi
RA   Wang, John
RA   Nomoto, Kenichi
RA   Pollock, Pamela M.
RT   "Sensitivity to the MEK inhibitor E6201 in melanoma cells is
RT   associated with mutant BRAF and wildtype PTEN status.";
RL   Mol. Cancer 11:75.1-75.15(2012).
//