ID   AG00780
AC   CVCL_U282
SY   AG 780; AG780; AG00780F; GM00780; GM-780; GM 780; GM780
DR   CLO; CLO_0036916
DR   Coriell; AG00780
DR   Coriell; GM00780
DR   GEO; GSM1184264
DR   GEO; GSM1184265
DR   GEO; GSM1535458
DR   GEO; GSM1535467
DR   Wikidata; Q54609418
RX   CelloPub=CLPUB00387;
RX   CelloPub=CLPUB00597;
RX   PubMed=6223188;
RX   PubMed=7176709;
RX   PubMed=7253718;
RX   PubMed=24749076;
CC   Sequence variation: Mutation; HGNC; 12791; WRN; Simple; p.Arg369Ter (c.1105C>T) (c.1336C>T); ClinVar=VCV000005449; Zygosity=Homozygous (Coriell=GM00780).
CC   Omics: miRNA expression profiling.
CC   Omics: Transcriptome analysis by microarray.
CC   Discontinued: Coriell; GM00780; probable.
CC   Derived from site: In situ; Skin; UBERON=UBERON_0002097.
CC   Cell type: Fibroblast of skin; CL=CL_0002620.
DI   NCIt; C3447; Werner syndrome
DI   ORDO; Orphanet_902; Werner syndrome
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
SX   Male
AG   60Y
CA   Finite cell line
DT   Created: 03-02-14; Last updated: 30-01-24; Version: 18
RX   CelloPub=CLPUB00387;
RA   Coriell L.L., Greene A.E., Mulivor R.A.;
RT   "The human genetic mutant cell repository: list of genetic variants,
RT   chromosomal aberrations and normal cell cultures submitted to the
RT   repository. 7th edition. October 1980.";
RL   (In) Institute for Medical Research (Camden, N.J.) NIH 80-2011; pp.1-254; National Institutes of Health; Bethesda (1980).
RX   CelloPub=CLPUB00597;
RG   National Institute on Aging;
RT   "1994 catalog of cell lines. NIA Aging Cell Repository.";
RL   (In) Institute for Medical Research (Camden, N.J.); pp.1-351; National Institutes of Health; Bethesda (1994).
RX   PubMed=6223188; DOI=10.1016/0047-6374(83)90071-4;
RA   Chapman M.L., Zaun M.R., Gracy R.W.;
RT   "Changes in NAD levels in human lymphocytes and fibroblasts during
RT   aging and in premature aging syndromes.";
RL   Mech. Ageing Dev. 21:157-167(1983).
RX   PubMed=7176709; DOI=10.1016/0047-6374(82)90061-6;
RA   Tollefsbol T.O., Zaun M.R., Gracy R.W.;
RT   "Increased lability of triosephosphate isomerase in progeria and
RT   Werner's syndrome fibroblasts.";
RL   Mech. Ageing Dev. 20:93-101(1982).
RX   PubMed=7253718; DOI=10.1016/0047-6374(81)90027-0;
RA   Das N.K., Murphy D.G.;
RT   "The National Institute on Aging repository cell cultures.";
RL   Mech. Ageing Dev. 16:1-17(1981).
RX   PubMed=24749076; DOI=10.1016/j.stemcr.2014.02.006;
RA   Cheung H.-H., Liu X.-Z., Canterel-Thouennon L., Li L., Edmonson C.,
RA   Rennert O.M.;
RT   "Telomerase protects Werner syndrome lineage-specific stem cells from
RT   premature aging.";
RL   Stem Cell Reports 2:534-546(2014).