ID   PC-9/f9
AC   CVCL_U150
SY   PC-9-f9; PC9/f9
DR   cancercelllines; CVCL_U150
DR   Cosmic; 915330
DR   Wikidata; Q54938493
RX   PubMed=11078804;
RX   PubMed=11506965;
RX   PubMed=12696064;
CC   Population: Chinese; Han and Japanese.
CC   Characteristics: Highly metastatic. Established after nine passages of the parent cell line in nude mice (PubMed=11078804).
CC   Sequence variation: Mutation; HGNC; HGNC:3236; EGFR; Simple; p.Glu746_Ala750del (c.2235_2249del15); ClinVar=VCV000163343; Zygosity=Unspecified (from parent cell line).
CC   Sequence variation: Mutation; HGNC; HGNC:11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Omics: Transcriptomics; Microarray.
CC   Derived from site: Metastatic; Lymph node; UBERON=UBERON_0000029.
DI   NCIt; C3512; Lung adenocarcinoma
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_B260 ! PC-9
SX   Male
AG   45Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 10-04-25; Version: 19
//
RX   PubMed=11078804; DOI=10.3892/ijo.17.6.1187;
RA   Takenaka K., Shibuya M., Takeda Y., Hibino S., Gemma A., Ono Y.,
RA   Kudoh S.;
RT   "Altered expression and function of beta1 integrins in a highly
RT   metastatic human lung adenocarcinoma cell line.";
RL   Int. J. Oncol. 17:1187-1194(2000).
//
RX   PubMed=11506965; DOI=10.1016/S0959-8049(01)00154-X;
RA   Gemma A., Takenaka K., Hosoya Y., Matuda K., Seike M., Kurimoto F.,
RA   Ono Y., Uematsu K., Takeda Y., Hibino S., Yoshimura A., Shibuya M.,
RA   Kudoh S.;
RT   "Altered expression of several genes in highly metastatic
RT   subpopulations of a human pulmonary adenocarcinoma cell line.";
RL   Eur. J. Cancer 37:1554-1561(2001).
//
RX   PubMed=12696064; DOI=10.1002/gcc.10205;
RA   Yoshimura A., Gemma A., Hosoya Y., Komaki E., Hosomi Y., Okano T.,
RA   Takenaka K., Matuda K., Seike M., Uematsu K., Hibino S., Shibuya M.,
RA   Yamada T., Hirohashi S., Kudoh S.;
RT   "Increased expression of the LGALS3 (galectin 3) gene in human
RT   non-small-cell lung cancer.";
RL   Genes Chromosomes Cancer 37:159-164(2003).
//