ID   NB4-LR2
AC   CVCL_U081
SY   NB4-R2
DR   BTO; BTO:0006044
DR   cancercelllines; CVCL_U081
DR   Wikidata; Q54907533
RX   PubMed=7915840;
RX   PubMed=10673742;
RX   PubMed=11704857;
CC   Population: Caucasian.
CC   Sequence variation: Gene fusion; HGNC; 9113; PML + HGNC; 9864; RARA; Name(s)=PML-RARA (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 6407; KRAS; Simple; p.Ala18Asp (c.53C>A); Zygosity=Heterozygous (from parent cell line).
CC   Sequence variation: Mutation; HGNC; 11998; TP53; Simple; p.Arg248Gln (c.743G>A); ClinVar=VCV000012356; Zygosity=Homozygous (from parent cell line).
CC   Derived from site: In situ; Bone marrow; UBERON=UBERON_0002371.
DI   NCIt; C3182; Acute promyelocytic leukemia with PML-RARA
DI   ORDO; Orphanet_520; Acute promyelocytic leukemia
OX   NCBI_TaxID=9606; ! Homo sapiens (Human)
HI   CVCL_8811 ! NB4-LR1
SX   Female
AG   23Y
CA   Cancer cell line
DT   Created: 03-02-14; Last updated: 05-10-23; Version: 17
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RX   PubMed=7915840; DOI=10.1073/pnas.91.18.8428;
RA   Ruchaud S., Duprez E., Gendron M.C., Houge G., Genieser H.-G.,
RA   Jastorff B., Doskeland S.O., Lanotte M.;
RT   "Two distinctly regulated events, priming and triggering, during
RT   retinoid-induced maturation and resistance of NB4 promyelocytic
RT   leukemia cell line.";
RL   Proc. Natl. Acad. Sci. U.S.A. 91:8428-8432(1994).
//
RX   PubMed=10673742; DOI=10.1038/sj.leu.2401683;
RA   Duprez E., Benoit G., Flexor M., Lillehaug J.R., Lanotte M.;
RT   "A mutated PML/RARA found in the retinoid maturation resistant NB4
RT   subclone, NB4-R2, blocks RARA and wild-type PML/RARA transcriptional
RT   activities.";
RL   Leukemia 14:255-261(2000).
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RX   PubMed=11704857; DOI=10.1038/sj.onc.1204863;
RA   Roussel M.J.S., Lanotte M.;
RT   "Maturation sensitive and resistant t(15;17) NB4 cell lines as tools
RT   for APL physiopathology: nomenclature of cells and repertory of their
RT   known genetic alterations and phenotypes.";
RL   Oncogene 20:7287-7291(2001).
//