ID   CHO-SPB-1
AC   CVCL_T760
SY   SPB-1
DR   CLO; CLO_0050414
DR   RCB; RCB1696
DR   Wikidata; Q54813108
RX   PubMed=1429697;
RX   PubMed=2125045;
RX   PubMed=9837968;
CC   Characteristics: Has a thermolabile serine palmitoyltransferase 1 (Sptlc1) (PubMed=2125045).
CC   Transformant: ChEBI; CHEBI_23994; Ethyl methanesulfonate (Methylsulfonic acid ethyl ester; MSEE).
CC   Derived from site: In situ; Ovary; UBERON=UBERON_0000992.
CC   Cell type: Epithelial cell of ovary; CL=CL_2000064.
OX   NCBI_TaxID=10029; ! Cricetulus griseus (Chinese hamster)
HI   CVCL_0214 ! CHO-K1
SX   Female
AG   Adult
CA   Spontaneously immortalized cell line
DT   Created: 03-02-14; Last updated: 19-12-24; Version: 10
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RX   PubMed=1429697; DOI=10.1016/S0021-9258(18)35871-X;
RA   Hanada K., Nishijima M., Kiso M., Hasegawa A., Fujita S., Ogawa T.,
RA   Akamatsu Y.;
RT   "Sphingolipids are essential for the growth of Chinese hamster ovary
RT   cells. Restoration of the growth of a mutant defective in sphingoid
RT   base biosynthesis by exogenous sphingolipids.";
RL   J. Biol. Chem. 267:23527-23533(1992).
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RX   PubMed=2125045; DOI=10.1016/S0021-9258(18)45681-5;
RA   Hanada K., Nishijima M., Akamatsu Y.;
RT   "A temperature-sensitive mammalian cell mutant with thermolabile
RT   serine palmitoyltransferase for the sphingolipid biosynthesis.";
RL   J. Biol. Chem. 265:22137-22142(1990).
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RX   PubMed=9837968; DOI=10.1074/jbc.273.50.33787;
RA   Hanada K., Hara T., Fukasawa M., Yamaji A., Umeda M., Nishijima M.;
RT   "Mammalian cell mutants resistant to a sphingomyelin-directed
RT   cytolysin. Genetic and biochemical evidence for complex formation of
RT   the LCB1 protein with the LCB2 protein for serine
RT   palmitoyltransferase.";
RL   J. Biol. Chem. 273:33787-33794(1998).
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